A comparative study of some convulsant substances as gamma-aminobutyric acid antagonists in the feline cerebral cortex

British Journal of Pharmacology
R G HillD W Straughan

Abstract

1. By the use of microiontophoretic techniques, quantitative estimates were obtained of the depressant effects of gamma-aminobutyric acid (GABA) on single feline cortical neurones.2. Picrotoxin, bicuculline, strychnine, (+)-tubocurarine, penicillin and leptazol were also applied microiontophoretically to single neurones. Sequential GABA applications were made before, during and after the microiontophoresis of these substances and any effects on the time course of the GABA depression were measured as an estimate of antagonism or potentiation of GABA.3. (+)-Tubocurarine was found to be a potent GABA antagonist. Picrotoxin and bicuculline were rather less potent and strychnine and penicillin only weakly active as GABA antagonists. Leptazol appeared to be inactive against GABA depressions.4. In addition, bicuculline and strychnine were found to be capable of potentiating the depressant action of GABA. This property was not shared by the other substances studied.5. All the substances studied produced changes in neuronal firing rate that did not correlate with GABA antagonism.6. In conclusion, several potent convulsants have been shown to be capable of GABA antagonism. It is not yet clear that this effect, rather than a direct effect...Continue Reading

References

Feb 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·W Löscher, H H Frey
Jul 1, 1979·Electroencephalography and Clinical Neurophysiology·J B Macon, D W King
Jan 1, 1980·Electroencephalography and Clinical Neurophysiology·J D GlassA S Chattha
Jun 1, 1974·Neuropharmacology·D W Straughan
May 1, 1975·Neuropharmacology·C BianchiA Bertelli
Jul 1, 1983·Neuropharmacology·D Tsoucaris-KupferH Schmitt
Jan 1, 1983·Neuropharmacology·M Del ZompoJ F Tallman
Sep 1, 1979·Pharmacology, Biochemistry, and Behavior·M S MyslobodskyJ Engel
Jan 1, 1981·Pharmacology, Biochemistry, and Behavior·M S MyslobodskyM Mintz
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Jan 1, 1978·Progress in Neurobiology·Y Kudo
Jan 1, 1980·Progress in Neurobiology·A Dray
Sep 1, 1981·Brain Research Bulletin·E W SnyderD E Shearer
May 1, 1976·British Journal of Pharmacology·K Okamoto, J H Quastel
Jan 1, 1978·British Journal of Pharmacology·W Feldberg, M Rocha e Silva
Sep 1, 1974·British Journal of Pharmacology·D R CurtisR M McCulloch
Feb 22, 2013·British Journal of Pharmacology·Graham A R Johnston
Jan 1, 1975·Experimental Neurology·G M McKenzie, K Viik

Citations

Oct 1, 1967·The Journal of Physiology·J W Phillis, A K Tebĕcis
Jan 1, 1969·Experimental Brain Research·J S Kelly, K Krnjević
Apr 1, 1970·Brain Research·I Engberg, A Thaller
Oct 8, 1971·Brain Research·D R CurtisH McLennan
Jun 27, 1970·Nature·D R CurtisG A Johnston
Oct 10, 1970·Nature·K Krnjević
Nov 3, 1972·Nature·R G HillD W Straughan
Oct 1, 1971·Nature·D W StraughanR G Hill
May 1, 1966·The Journal of Physiology·K KrnjevićD W Straughan
Apr 1, 1972·British Journal of Pharmacology·R G HillD W Straughan
Aug 11, 1972·Brain Research·D R CurtisR M MacLachlan
Jun 29, 1971·Experimental Brain Research·D R CurtisG A Johnston
Jul 1, 1971·Neurology·M J Gutnick, D A Prince
Nov 1, 1969·The Journal of Physiology·A Takeuchi, N Takeuchi
Apr 1, 1970·British Journal of Pharmacology·E S JohnsonD W Straughan
Nov 14, 1970·Nature·J M GodfraindR Pumain
Jan 1, 1968·Experimental Brain Research·D R CurtisG A Johnston
Aug 1, 1969·Brain Research·D R CurtisG A Johnston
Oct 31, 1958·The Journal of Physiology·J ROBBINS, W G VAN DER KLOOT
Sep 1, 1963·The Journal of Pharmacy and Pharmacology·P W RAMWELL, J E SHAW

Related Concepts

Family Felidae
Plant alkaloid
Strychnine Assay
Aminobutyrates
Neurons
Action Potentials
GABA Antagonists
Molecular_function
Picrotoxin
Diagnostic Techniques, Surgical

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.