Abstract
Allergen-specific immunotherapy (ASIT) is the only causative treatment of canine atopic dermatitis (cAD). Different routes for administration of ASIT have been used; however, comparative studies are lacking. The present study compared the efficacy and safety of subcutaneous (SCIT), intralymphatic (ILIT) and sublingual (SLIT) immunotherapy. 30 atopic dogs were included and allocation to three groups (SCIT, n = 8; ILIT, n = 12; SLIT, n = 10) was determined by the owners. ASIT was administered using routine protocols. The pruritus Visual Analog Scale (PVAS), canine atopic dermatitis extent and severity index (CADESI), concurrent medications and adverse events were recorded initially and one, three, six and 12 months later. The main outcome measure was return to a normal status, which included CADESI <12, PVAS <2.5 and medication score <10. Drop-outs were distributed evenly and 23 dogs finished the study (SCIT, n = 6; ILIT, n = 10; SLIT, n = 7). Adverse reactions to treatment were rare. At the start of the study, the three groups were homogeneous with respect to clinical signs and concurrent medications. After 12 months of ASIT, the CADESI and PVAS had decreased with a stable medication score in the ILIT and SCIT groups (P < 0.05),...Continue Reading
References
Apr 1, 1997·Immunological Reviews·R M ZinkernagelH Hengartner
Sep 13, 2001·Veterinary Immunology and Immunopathology·C E Griffin, A Hillier
Sep 29, 2004·Veterinary Immunology and Immunopathology·Masayuki ShidaToshiroh Iwasaki
Jan 24, 2006·The Veterinary Record·B SchnablR S Mueller
Sep 29, 2006·Veterinary Immunology and Immunopathology·Richard Halliwell
Apr 9, 2008·Trends in Molecular Medicine·Natalija NovakJean-Pierre Allam
Jan 28, 2009·Veterinary Dermatology·J RybnícekP B Hill
Mar 27, 2009·Veterinary Dermatology·Christine Loewenstein, Ralf S Mueller
Aug 15, 2009·Current Opinion in Allergy and Clinical Immunology·Gabriela SentiThomas M Kündig
Mar 2, 2010·Veterinary Dermatology·Claude FavrotFedericca Picco
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Cezmi A Akdis, Mübeccel Akdis
Oct 15, 2011·The Journal of Allergy and Clinical Immunology·Gabriela SentiThomas M Kündig
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Gabriela SentiThomas M Kündig
Jul 7, 2012·Journal of the American Veterinary Medical Association·Rosanna MarsellaValerie A Fadok
Feb 26, 2013·The Veterinary Record·Tim NuttallRichard Halliwell
Jan 28, 2014·Veterinary Dermatology·Thierry OlivryUNKNOWN International Committe on Allergic Diseases of Animals (ICADA)
Jul 15, 2015·The Journal of Allergy and Clinical Immunology·Marek JutelCezmi A Akdis
Jan 11, 2016·Veterinary Dermatology·Douglas J DeBoerMary Morris
Sep 23, 2016·Schweizer Archiv für Tierheilkunde·N FischerC Favrot
Mar 13, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Matthew GreenhawtDana Wallace
Jan 13, 2018·Veterinary Dermatology·Katrin TimmClaudia S Nett-Mettler
Jun 19, 2018·Veterinary Dermatology·Nina FischerClaude Favrot
Sep 20, 2018·The Veterinary Clinics of North America. Small Animal Practice·Ralf S Mueller