PMID: 9169568Jun 1, 1997Paper

A comparative study of technetium-99m sestamibi and technetium-99m tetrofosmin single-photon tomography in the detection of nasopharyngeal carcinoma

European Journal of Nuclear Medicine
L KostakogluC Bekdik

Abstract

The intention of this prospective study was to compare the diagnostic potential of technetium-99m sestamibi (MIBI) and a novel radiotracer, 99mTc-Tetrofosmin (Tetro), for the assessment of primary nasopharyngeal carcinoma (NPC) and the differentiation of residual disease from post-therapy changes. A total of 38 patients underwent MIBI and Tetro single-photon emission tomography (SPET) imaging at initial presentation (n=22) or following therapy (n=16). The findings were correlated with computed tomography or magnetic resonance imaging (MRI) on a site-by-site basis. Tumour/background (Tm/Bkg) ratios were obtained on coronal sections. Biopsy (nine patients) and/or 12- to 24-month clinical follow-up data were available in the post-therapy group. All primary disease sites were accurately detected by both imaging studies. Although there was no statistical difference between the two imaging techniques in the detection of primary disease, MIBI was superior to Tetro in the detection of regional lymph node metastases (sensitivity: 95% vs 79%). Tetro and MIBI SPET were true-positive in all patients (n=7) with proven residual/recurrent disease. In nine patients who had no evidence of residual/recurrent tumour, MRI was false-positive in fiv...Continue Reading

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Citations

Oct 7, 2000·Annals of Nuclear Medicine·T HashimotoM Goto
Jun 7, 2003·Annals of Nuclear Medicine·Zeynep YaparMehmet Emin Inal
Dec 5, 1998·Annals of Nuclear Medicine·T TakayamaN Tonami
Mar 22, 2005·Cancer Biotherapy & Radiopharmaceuticals·Bruno FattoriGiuliano Mariani
Mar 30, 2007·Journal of Endocrinological Investigation·N KurtulmusA Mudun

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