A Comparative Study of the Amount of Bleeding and Hemodynamic Changes between Dexmedetomidine Infusion and Remifentanil Infusion for Controlled Hypotensive Anesthesia in Lumbar Discopathy Surgery: A Double-Blind, Randomized, Clinical Trial

Anesthesiology and Pain Medicine
Fatemeh JavaherforooshzadehHesam Saeed

Abstract

The aim of this study was to compare the volume of blood loss and hemodynamic changes in patients undergoing lumbar discopathy, after continuous infusions of dexmedetomidine versus remifentanil during anesthesia with controlled low blood pressure. In this randomized double-blind clinical trial, 60 patients aged 20 to 65 years were randomly assigned to control and intervention groups. The intervention group received a continuous infusion of dexmedetomidine at 0.3 - 0.7 µg/kg/hour plus propofol at 50 - 100 µg/kg/minute. The control group was given a continuous infusion of remifentanil at 0.1 to 1 µg/kg/minute plus the same dose of propofol as above. The primary outcome was the amount of patient's bleeding during surgery, and secondary outcomes were changes in the patient's systolic blood pressure, diastolic blood pressure, mean arterial pressure, and urinary output. Univariate and multivariate analyses of the main outcome in the control and intervention groups showed that there was no significant difference between the two drugs with regards to the volume of blood loss, mean arterial pressure, and systolic and diastolic blood pressure. Postoperative side effects were significantly lower in the intervention group (P = 0.002). Admi...Continue Reading

References

Jan 24, 2007·European Journal of Anaesthesiology·M DurmusM O Ersoy
May 10, 2007·Drugs·Christian-Serge Degoute
Oct 22, 2008·Journal of Clinical Anesthesia·Hilal AyogluIsil Ozkocak
Aug 21, 2013·The Annals of Otology, Rhinology, and Laryngology·Jungah LeeHyerim Kang
Apr 1, 2012·Anesthesiology and Pain Medicine·Zahra Taghipour AnvariMasood Mohseni
Jul 30, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Safinaz KarabayirliNebil Ark

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Citations

Sep 10, 2019·Anesthesiology and Pain Medicine·Fatemeh Javaherforoosh ZadehMansoor Soltanzadeh
Mar 19, 2019·Anesthesiology and Pain Medicine·Farahzad JanatmakanMahshid Vaziri
Jul 24, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Farhad SoltaniFarahmand Kalantari
Oct 8, 2020·Molecular Biology Reports·Fatemeh Javaherforoosh ZadehHadi Rezaeeyan

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Methods Mentioned

BETA
sedation

Software Mentioned

SPSS

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