PMID: 2507909Oct 1, 1989Paper

A comparative study of the antimutagenic effects of antioxidants on chemical mutagenesis in Drosophila melanogaster

Mutation Research
R I Goncharova, T D Kuzhir

Abstract

The 1,4-dihydropyridine derivative 2,6-dimethyl-3,5-diethoxycarbonyl-4-(Na carboxylate)-1,4-dihydropyridine (1,4-DHP) was studied for antimutagenic effects in the dominant lethal test and in the sex-linked recessive lethal test of Drosophila melanogaster. The observed effects were compared with those of the radioprotectors cysteine and cysteamine and with those of the phenolic antioxidant butylated hydroxytoluene (BHT). In a wide range of concentrations, including low ones, 1,4-DHP reduces the frequency of EMS-induced genetic damage (point mutations and chromosome breakage). A reduction of the mutation rate induced by EMS in adults could be observed independently of the developmental stages (larvae or imago) pretreated with 1,4-DHP. The protective effect of this new antimutagen against the alkylating agent depended on both the 1,4-DHP dose and the level of the EMS-induced mutation rate. The effect of 1,4-DHP was more pronounced than that of the studied radioprotectors. It is concluded that dihydropyridine-type compounds are able to protect eukaryote germs cells from genetic damage produced by direct-acting mutagens such as EMS.

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Citations

Jun 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Bose, S P Sinha
Aug 16, 2012·Journal of Medicinal Food·Laura Vicedo JacociunasRafael Rodrigues Dihl
Aug 8, 2009·Mutation Research·Nadezhda I RyabokonJoanna Rzeszowska-Wolny
Oct 25, 2002·International Journal of Toxicology·Rebecca S Lanigan, Torill A Yamarik
Aug 21, 2012·Toxicology and Industrial Health·Kadir TurhanMedine Gulluce
Jul 10, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·B Çelik, H Özparlak
Jan 14, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Monalisa Mishra, Usha R Acharya
Oct 16, 2007·Mutation Research·Nadezhda I RyabokonJoanna Rzeszowska-Wolny

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