PMID: 4897460Sep 1, 1969Paper

A comparative study of the effect of aflatoxin B and actinomycin D on HeLa cells

The Biochemical Journal
E H Harley, K R Rees

Abstract

1. The cytotoxic effects of aflatoxin B(1) on HeLa cells were examined and effects of short exposures of the cells to the toxin were found to be reversible. 2. Aflatoxin B(1) inhibited the synthesis of both ribosomal and heterodisperse RNA. It is proposed that the toxin's mechanism of action on ribosomal RNA synthesis is related to its inhibitory effect on the maturation of the 45s-ribosomal-RNA precursor. 3. Protein synthesis is inhibited to a greater extent by aflatoxin B(1) than by actinomycin D. In contrast with actinomycin D, aflatoxin B(1) was shown to disaggregate polyribosomes directly.

Citations

Mar 1, 1974·European Journal of Biochemistry·E O AkinrimisiK H Seifart
Jul 1, 1980·Bulletin of Environmental Contamination and Toxicology·B J McCoy, G C Llewellyn
Sep 1, 1973·Toxicology and Applied Pharmacology·K M al-AdilR P Painter
Jan 1, 1972·Zeitschrift für allgemeine Mikrobiologie·O U Eka
Sep 1, 1972·Journal of Dairy Science·G P Lynch
Oct 30, 1970·Annals of the New York Academy of Sciences·G N Wogan, R S Pong
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin Klvana, Urban Bren
Feb 1, 1995·Pharmacology & Therapeutics·M McLean, M F Dutton
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Jan 1, 1979·General Pharmacology·N Mohapatra, J F Roberts
Jul 1, 1972·Chemico-biological Interactions·L E CrookK R Rees
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Jan 1, 1985·Applied and Environmental Microbiology·J Coallier-Ascah, E S Idziak
Jun 1, 1971·Experimental and Molecular Pathology·F CajoneM Bassi

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