PMID: 6980064Apr 1, 1982Paper

A comparative study of the effect of oestrogen substitution therapy on breast development in girls with hypo- and hypergonadotrophic hypogonadism

Clinical Endocrinology
A PertzelanZ Laron

Abstract

During treatment of girls with oestrogen deficiency we observed different patterns of breast development in response to therapy. The forty-five girls studied fell into four groups: Group A, gonadal dysgenesis; Group B, isolated gonadotrophin deficiency; Group C, multiple pituitary hormone deficiencies; Group D, congenital adrenal hyperplasia (17-alpha-hydroxylase deficiency). Treatment with oestrogen was given in an identical manner to all. In the patients with gonadal dysgenesis, in whom the hypothalamic-pituitary function was normal, treatment led to full breast development. In isolated gonadotrophin deficiency and multiple pituitary hormone deficiency breast development was incomplete even after 3 years or more of oestrogen treatment. The conspicuous difference in the hormonal status is that the latter two groups lack gonadotrophins, while in gonadal dysgenesis these hormones are grossly elevated. Our conclusion is that gonadotrophins play an important role in mammary gland development, a finding not previously described. In the girl with 17-alpha-hydroxylase deficiency we observed that cortisol was necessary, in addition to sex hormones, for normal breast development.

References

Sep 1, 1976·The Journal of Pediatrics·A K KershnarM Schambelan
Jan 1, 1977·Advances in Experimental Medicine and Biology·L S Jacobs
Nov 1, 1977·Clinical Endocrinology·A PertzelanZ Laron
Jul 1, 1974·The Journal of Investigative Dermatology·R L Ceriani
Jul 1, 1974·The Journal of Investigative Dermatology·J C Porter
Jan 1, 1970·Current Topics in Pathology. Ergebnisse Der Pathologie·R Bässler
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Feb 1, 1980·Pediatric Clinics of North America·J W Finkelstein
Oct 1, 1980·Physiological Reviews·Y J Topper, C S Freeman
Jun 1, 1981·Clinical Endocrinology·E C BurnsN Cameron
Jun 1, 1980·European Journal of Pediatrics·Z LaronA Pertzelan

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Citations

Nov 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·R J King
Sep 1, 1997·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Z Harel, S Riggs
Jan 1, 1986·Annals of the New York Academy of Sciences·J O Drife
Jul 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S A MendozaB M Tune
May 31, 2002·The British Journal of Radiology·B BembiR J Wenstrup
Nov 28, 2019·Human Reproduction·Tim C van de GriftUNKNOWN dsd-LIFE
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Harold E CarlsonC V Rao
Jun 17, 2000·Endocrine Reviews·P C White, P W Speiser

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