A comparative study of the incidence of aseptic meningitis in symptomatic natural mumps patients and monovalent mumps vaccine recipients in Japan

Vaccine
Takao NagaiTetsuo Nakayama

Abstract

To compare the incidence of aseptic meningitis associated with symptomatic natural mumps infection and in mumps vaccine recipients, we conducted a prospective comparative study. Consecutive samples of 1051 children with mumps were enrolled by 10 pediatricians and 21,465 vaccine recipients by 143 pediatric primary care practitioners, from January 1, 2000 to January 1, 2003. Parents used a daily diary to record symptoms during the period of illness (15 days) or 30-day period following immunization. Mumps infection was confirmed by virus isolation and/or detection of mumps virus genome in salivary and CSF samples. The incidence of aseptic meningitis was 13/1051 (1.24%) in patients with symptomatic natural mumps infection and was estimated to be 0.7-1.1% of overall infection in considering asymptomatic infection, and 10/21,465 (0.05%) in vaccine recipients. Although aseptic meningitis is a clear side effect of the mumps vaccine, the incidence is considerably lower than among those with symptomatic natural infection. Our results provide an informative data for consideration to resume mumps vaccine as a part of routine immunization schedule for Japanese children.

References

Jan 1, 1992·The Journal of Infectious Diseases·T NakayamaS Makino
Mar 1, 1991·The Pediatric Infectious Disease Journal·A Sugiura, A Yamada
Sep 1, 1989·Virology·A YamadaA Sugiura
Nov 1, 1973·The Tohoku Journal of Experimental Medicine·Y ChibaS Chiba
Jun 1, 1996·Acta Paediatrica Japonica; Overseas Edition·M KimuraR Murata
Dec 1, 1995·International Journal of Epidemiology·I Rebiere, C Galy-Eyraud
Aug 27, 1998·Journal of Tropical Pediatrics·J KatzR P Pohkrel
May 5, 1999·Archives of Virology·Y KashiwagiT Nakayama
Aug 10, 2001·Current Opinion in Microbiology·K M CarboneM V Pletnikov
Mar 26, 2004·Journal of Medical Virology·Yoko InouChiaki Miyazaki

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Citations

Mar 12, 2010·Uirusu·Tetsuo Nakayama
Jan 5, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Keita MatsubaraTetsuo Nakayama
Jul 15, 2015·Rinshō shinkeigaku = Clinical neurology·Shinichi TakeshimaMasaru Kuriyama
Sep 18, 2014·The Journal of Pathology·Steven RubinW Paul Duprex
Mar 27, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Kenichi SugaKazuhiro Mori
Jul 10, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tetsuo Nakayama
Nov 10, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Akihito SawadaTetsuo Nakayama
Dec 30, 2014·Journal of the Neurological Sciences·Jun-Ichi TakanashiMasashi Mizuguchi
Dec 23, 2016·Japanese Journal of Infectious Diseases·Yumani KubaMinoru Kidokoro
Jul 19, 2013·PloS One·Keita MatsubaraTetsuo Nakayama
Oct 22, 2013·Arquivos de neuro-psiquiatria·Marcus Tulius T Silva
Mar 18, 2008·Lancet·Anders HviidKathrin Mühlemann
Apr 23, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Kihei TeradaKazunobu Ouchi
Jun 13, 2017·Human Vaccines & Immunotherapeutics·Yusuke TanakaTadashi Kimura
May 24, 2013·Japanese Journal of Infectious Diseases·Tomoko Soga Momoki
Jun 13, 2020·Human Vaccines & Immunotherapeutics·Taito Kitano
Jan 1, 2019·Uirusu·Minoru Kidokoro
Nov 12, 2015·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Kihei TeradaSeiko Kitagawa
Dec 15, 2020·Pediatric Transplantation·Takanori FunakiIsao Miyairi

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