A comparative study of the local cytokine response in the lungs of pigs experimentally infected with different PRRSV-1 strains: upregulation of IL-1α in highly pathogenic strain induced lesions

Veterinary Immunology and Immunopathology
Shyrley P AmarillaFrancisco J Salguero

Abstract

Porcine reproductive and respiratory syndrome viruses (PRRSV) show high genetic differences both among and within genotypes. Recently, several highly pathogenic PRRSV (HP-PRRSV) strains have been described. This study compares and characterizes the production of cytokines by pulmonary macrophages in pigs experimentally infected with four different PRRSV-1 strains: two low-virulent strains, Lelystad (LV) and a British field strain (215-06); a HP strain (SU1-bel) from Belarus and the attenuated vaccine strain DV (Porcilis(®) PRRS). Animals were clinically monitored and post-mortem examinations were performed at 3, 7 and 35 days post-infection (dpi). Lung samples were processed for histopathological and immunohistochemical studies by using specific antibodies against PRRSV, IL1-α, IL-6, TNF-α, IL-10 and IFN-γ. SU1-bel infected animals presented the highest mean scores for clinical observations, gross and microscopic lesions as well as for PRRSV expression compared with the other infected groups (p≤0.027). These animals displayed the highest expression of IL1-α at 7dpi, together with the highest score for lung pathology, whereas LV, 215-06 and DV inoculated animals only showed a transient enhancement in some of these cytokines. SU1...Continue Reading

References

Jan 1, 1996·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·P G HalburJ A Rathje
Jun 20, 2002·Veterinary Immunology and Immunopathology·Kristien Van ReethMaurice Pensaert
May 17, 2005·Journal of Comparative Pathology·F J SalgueroJ C Gómez-Villamandos
May 27, 2011·Veterinary Immunology and Immunopathology·Gang WangEn-Min Zhou
Dec 26, 2012·The Veterinary Journal·Jaime Gómez-LagunaLibrado Carrasco
Aug 14, 2013·The Journal of General Virology·Eric J SnijderYing Fang
Sep 26, 2013·Frontiers in Microbiology·Hirokazu KimuraAkihide Ryo
Apr 15, 2014·Veterinary Immunology and Immunopathology·Obdulio García-NicolásFrancisco José Pallarés

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Citations

Dec 10, 2015·Annual Review of Animal Biosciences·Joan K LunneyGourapura J Renukaradhya
Jun 29, 2016·Current Opinion in Microbiology·Alayna K Caffrey, Joshua J Obar
May 14, 2016·Journal of Virology·Adam L BaileyDavid H O'Connor
Sep 28, 2017·Infection and Immunity·Alayna K Caffrey-CarrJoshua J Obar
May 20, 2019·Veterinary Research Communications·Jose M Sánchez-CarvajalJaime Gómez-Laguna
Jul 11, 2021·Veterinary Microbiology·I Ruedas-TorresJ Gómez-Laguna

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