PMID: 9428499Jan 15, 1998Paper

A comparative study of the long term psychosocial functioning of childhood acute lymphoblastic leukemia survivors treated by intrathecal methotrexate with or without cranial radiation

Cancer
J M HillJ C Holland

Abstract

Although previous research has delineated medical, cognitive, and neuropsychologic late effects of central nervous system (CNS) prophylaxis for childhood acute lymphoblastic leukemia (ALL), it has been difficult to draw conclusions about the long term psychosocial sequelae of these treatments due to methodologic problems that led to inconclusive results in past studies. In the current study, the authors examined the long term psychosocial functioning of childhood ALL survivors who had been treated on a Phase III clinical protocol (Cancer and Leukemia Group B [CALGB] 7611) between 1976 and 1979, in which they were randomized to receive either 2400 centigray of cranial radiation (CRT) with intrathecal methotrexate (IT-MTX) or intermediate dose systemic methotrexate (IV-MTX) with IT-MTX. One hundred ten survivors of childhood ALL (mean age, 20.8 years) treated on CALGB 7611 who were age 14 years or older and disease free for at least 1 year were studied a mean of 14.7 years after their entry on CALGB 7611. In a telephone interview, a psychosocial assessment battery was administered to the patients, consisting of measures that assessed psychologic, sexual, social, and vocational functioning as well as any delayed physical effects. ...Continue Reading

Citations

Jun 5, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E M Jenney, G A Levitt
Mar 23, 1999·Archives of Disease in Childhood·J RodgersJ Kernahan
Aug 4, 2001·BMJ : British Medical Journal·W H WallaceUNKNOWN Late Effects Committee of the United Kingdom Children's Cancer Study Group (UKCCSG)
Jan 23, 2003·Archives of Disease in Childhood·J RodgersK Windebank
Dec 3, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dorie A GloverUNKNOWN Children's Cancer Group
Jul 9, 2002·British Journal of Haematology·Alison D Leiper
Jun 2, 2009·Gynecologic Oncology·Kristina L Mirabeau-BealeUrsula A Matulonis
Oct 25, 2011·Psycho-oncology·Belinda ThewesCarolyn Gotay
Jul 23, 2014·Tropical Medicine & International Health : TM & IH·Alias HamidahVijayalakshmi C Ratnam
Jul 25, 2008·International Journal of Cancer. Journal International Du Cancer·Päivi M LähteenmäkiArja Harila-Saari
Feb 24, 2000·The Journal of School Health·K M Thies
Jul 25, 2009·Cancer·Jonathan BergmanMark S Litwin

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