A comparative study of the role of crocin and sitagliptin in attenuation of STZ-induced diabetes mellitus and the associated inflammatory and apoptotic changes in pancreatic β-islets

Environmental Toxicology and Pharmacology
Mahmoud M SamahaHatem A Salem

Abstract

Type 1 diabetes mellitus (T1DM) describes a complex group of metabolic disorders associated with elevated blood glucose levels and increased risks of complications development. Exploring new drug therapies would reduce the increased diabetes-associated morbidity and mortality and will reduce the excessive health care costs. Crocin is the major active ingredient of saffron. In the current study, DM was induced by single intraperitoneal injection of streptozocin (50 mg/kg).DM progression was associated with a significant increase in blood glucose level with reduced insulin and increased glucagon secretion. Pancreatic malondialdehyde (MDA) content significantly escalated, while superoxide dismutase (SOD) activity, reduced glutathione (GSH) concentration, catalase activity, thioredoxin level and serum total antioxidant capacity significantly declined. This was associated with a significant increase in pancreatic caspase-3 contents and pancreatic infiltration with inflammatory cells in β-islets. Both sitagliptin and crocin significantly reduced blood glucose levels, enhanced pancreatic insulin expression and secretion and suppressed glucagon secretion with enhancement of anti-oxidant defenses and reduction of oxidative burden, with ...Continue Reading

Citations

Aug 18, 2020·The Journal of Pharmacy and Pharmacology·Hongyu XiaoJian Liang
Aug 30, 2020·Cancers·Lenka KoklesovaPeter Kubatka
Jan 17, 2020·International Journal of Biological Macromolecules·Rui-Bo JiaMouming Zhao
Feb 6, 2021·Oxidative Medicine and Cellular Longevity·Xin SuYanwei Xing
Apr 30, 2020·Saudi Journal of Biological Sciences·Mardi M Algandaby
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahmoud HashemzaeiRamin Rezaee

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