A comparative study of the use of powder X-ray diffraction, Raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam

Journal of Pharmaceutical and Biomedical Analysis
Denise M CrokerBenjamin K Hodnett

Abstract

Diffraction and spectroscopic methods were evaluated for quantitative analysis of binary powder mixtures of FII(6.403) and FIII(6.525) piracetam. The two polymorphs of piracetam could be distinguished using powder X-ray diffraction (PXRD), Raman and near-infrared (NIR) spectroscopy. The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this polymorphic mixture. When the spectra are treated with the combination of multiplicative scatter correction (MSC) and second derivative data pretreatments, the partial least squared (PLS) regression model gave a root mean square error of calibration (RMSEC) of 0.94 and 0.99%, respectively. FIII(6.525) demonstrated some preferred orientation in PXRD analysis, making PXRD the least preferred method of quantification.

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Citations

Dec 3, 2013·Journal of Pharmaceutical and Biomedical Analysis·Frederico Luis Felipe Soares, Renato Lajarim Carneiro
Feb 24, 2016·International Journal of Pharmaceutics·Krisztina NikowitzGéza Regdon
Nov 22, 2014·Pharmaceutical Development and Technology·Qi ZhangXuefeng Mei
Feb 12, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S A SchönbichlerC W Huck
Apr 15, 2015·Advanced Drug Delivery Reviews·Amrit PaudelJukka Rantanen
Dec 17, 2014·Pharmaceutical Research·Jari Pekka PajanderMingshi Yang
May 31, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·P RajeshT Gnanasambandan
Jun 14, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Caoimhe A CantwellRichard A Murphy
Aug 25, 2020·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Zhixin ZhengHongxun Hao
Aug 8, 2015·Biomedical Chromatography : BMC·Gustavo D MendesGilberto De Nucci
Dec 19, 2020·Journal of AOAC International·Yongjun Lou, Lili Zuo

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