A comparative study of two intensified pulse cyclophosphamide remission-inducing regimens for diffuse proliferative lupus nephritis: an Egyptian experience.

International Urology and Nephrology
Alaa SabryAmr El-Huseini

Abstract

Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that is usually treated with an extended course of intravenous (IV) cyclophosphamide (CYC). Given the side effects of this regimen, we evaluated the short-term efficacy and toxicity of a course of low-dose remission-inducing IV CYC followed by azathioprine (AZA) in a prospective controlled study among Egyptian patients with severe LN. In this single center, prospective clinical trial, we assigned 46 SLE patients with diffuse proliferative glomerulonephritis to either a high-dose (a maximum of 1 g/dose) of IV CYC (HD-CYC) for six monthly pulses followed by two quarterly pulses or a fixed low-dose (500 mg/dose) of IV CYC (LD-CYC) for six fortnightly pulses with a cumulative dose of 3 g. Each regimen was followed by AZA. To compare between efficacy, potential toxicity and outcome of parenteral LD-CYC versus HD-CYC therapy for severe LN. Twenty patients (2 male and 18 female) received fortnightly fixed LD-CYC while 26 (5 male and 21 female) received monthly HD-CYC therapy. At the end of the study (1 year after starting therapy), there was no difference either in patients' or in renal survival in both groups. Significant improvement of disease activ...Continue Reading

References

Jun 1, 1989·The Journal of Pediatrics·T J LehmanA Kovalesky
Mar 6, 1986·The New England Journal of Medicine·H A AustinJ L Decker
Feb 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V K Bansal, J A Beto
Nov 14, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C Ponticelli
Jul 9, 1999·QJM : Monthly Journal of the Association of Physicians·L BonoJ A Hicks
Jul 19, 2002·Archives of Internal Medicine·Jackson T WrightUNKNOWN African American Study of Kidney Disease and Hypertension Study Group
Sep 7, 2002·Genes and Immunity·J A KellyJ B Harley
Jan 16, 2003·Arthritis and Rheumatism·Michelle PetriRobert A Brodsky
Sep 10, 2003·Current Opinion in Rheumatology·Insoo Kang, Sung Hwan Park
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert S FlancRobert C Atkins
Feb 20, 2004·The Cochrane Database of Systematic Reviews·R S FlancR C Atkins
May 12, 2004·Consciousness and Cognition·Diane M Zizak, Arthur S Reber
Mar 1, 2005·Lupus·P I SidiropoulosD T Boumpas
Mar 1, 2005·Lupus·H Tahir, D A Isenberg
Nov 25, 2005·The New England Journal of Medicine·W Joseph McCune
Mar 28, 2006·The American Journal of Medicine·Chi Chiu MokTak Cheung Au
Jul 6, 2006·Kidney International·C GrootscholtenUNKNOWN Dutch Working Party on Systemic Lupus Erythematosus

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Citations

Nov 8, 2008·International Urology and Nephrology·Daniel Abensur AthanazioWashington Luis Conrado dos-Santos
Nov 28, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lorna K HendersonAngela C Webster
Jul 19, 2014·Rheumatic Diseases Clinics of North America·Michael M Ward
Sep 18, 2012·Autoimmunity Reviews·Andrea T BorchersM Eric Gershwin
Jun 30, 2018·The Cochrane Database of Systematic Reviews·David J TunnicliffeGiovanni Fm Strippoli
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Lorna HendersonAngela C Webster
Sep 3, 2016·The Journal of Rheumatology·Jasvinder A SinghGeorge A Wells
Nov 9, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Yebei LiGaosi Xu
Jun 6, 2020·Current Rheumatology Reports·Myrto KostopoulouGeorge Bertsias

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