A comparative study on biological properties of novel nanostructured monticellite-based composites with hydroxyapatite bioceramic

Materials Science & Engineering. C, Materials for Biological Applications
Erfan Kalantari, Seyed Morteza Naghib

Abstract

In this research, novel monticellite/hydroxyapatite (HA) ceramic composites were successfully prepared by mechanical method. The ability of nanostructured monticellite-based ceramic composites to form a suitable bond to living hard tissues, and stimulate osteoblast-like cells proliferation may be different for various ratios of the reinforcement to monticellite matrix. The differences in physico-chemical characteristics, bone-like apatite formation, cytocompatibility, cell viability and in vitro osteogenic activity of nanostructured monticellite/HA ceramic composites were explored. The surface reactivity and bioactivity of the composite samples were evaluated in vitro in simulated body fluid (SBF). A comparative time- and dose-dependent MTT test showed that the ions release from nanostructured monticellite/HA composites dissolution significantly stimulated cell proliferation and growth than control at a certain concentration range. The cells viability exposed to the composite extract was higher than control and mineral material of bone (HA), illustrating that cytocompatibility was improved due to the presence of magnesium (Mg) and silicon (Si) elements in the composite structure. The comparative results of alkaline phosphatase ...Continue Reading

Citations

Nov 27, 2019·Progress in Biomaterials·Mojtaba Ansari
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Neda ShahbaziSeyed Morteza Naghib
Dec 9, 2019·ACS Biomaterials Science & Engineering·Lin ZhangShufang Wang
Sep 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhengmao LiYinghong Zhou

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