A comparative study on demographic, hematological, and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis

Annals of Hematology
H AgisK Geissler

Abstract

We studied the incidence of leukemia cutis (LC) in 381 consecutive patients with acute myeloid leukemia (AML) in a single institution and compared the demographic, hematological, and cytogenetic findings in AML patients with and without LC. We also examined the response to intensive chemotherapy, overall survival, and duration of remission in this patient population with regard to the presence of LC. The prevalence of LC was 3.7% in clinically diagnosed patients and 2.9% in biopsy-proven cases, respectively. Patients with and without LC did not differ with regard to age, sex, white blood cell counts, hemoglobin, fibrinogen, and platelet counts at diagnosis, but lactate dehydrogenase (LDH) was significantly higher in patients with LC. Various karyotype abnormalities were found, but in patients with LC numerical abnormalities of chromosome 8 were significantly more common ( P<0.0001). Patients with LC did not differ from patients without LC with regard to remission rate, but there was a trend towards shorter remission duration in patients with LC. We conclude that patients with LC have some features different from patients without this symptom. The increased frequency of numerical aberrations of chromosome 8 in patients with LC w...Continue Reading

Citations

Oct 4, 2002·Hematological Oncology
Sep 3, 2013·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sanjeev Kumar SharmaSomesh Gupta
Jan 20, 2012·The American Journal of Dermatopathology·Autumn M StarnesKord Honda
Dec 19, 2012·Indian Journal of Dermatology·Angoori G Rao, Indira Danturty
Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Rachita MisriSunanda Mahajan
Mar 12, 2011·Indian Journal of Dermatology, Venereology and Leprology·Anju RajBharath Rangarajan
Aug 1, 2013·Annals of Hematology·Boting WuShanhua Zou
Mar 27, 2012·Actas dermo-sifiliográficas·F Toledo-Alberola, J Guijarro-Llorca
Dec 20, 2007·American Journal of Clinical Pathology·Jeong Hee Cho-VegaFrancisco Vega
Oct 16, 2008·The Australasian Journal of Dermatology·Sarah WeinelJeffrey P Callen
Mar 23, 2012·International Journal of Dermatology·Laju M PatelW Clark Lambert
Nov 5, 2011·Journal of Cutaneous Pathology·Catalina Amador-OrtizJohn L Frater
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Maro OhanianZeev Estrov
Aug 1, 2012·Journal of Cutaneous Pathology·Seong RaBruce Robbins
Aug 14, 2012·Journal of Cutaneous Pathology·Marianna ShvartsbeynMary Ann Perle
Nov 26, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gunnar WagnerMichael Max Sachse
Jan 22, 2014·International Journal of Dermatology·Benzeeta PintoPrashant Sharma
Jul 21, 2009·Journal of Cutaneous Pathology·Crystal G ThomasWilma F Bergfeld
Sep 9, 2011·Actas dermo-sifiliográficas·F Toledo-Alberola, J Guijarro-Llorca
Apr 21, 2016·Blood Reviews·Melhem SolhAsad Bashey
Jul 1, 2011·Practical Radiation Oncology·Richard Bakst, Joachim Yahalom
Jul 29, 2011·Blood·Richard L BakstJoachim Yahalom
Jan 18, 2017·Journal of Cancer Research and Clinical Oncology·Khaled ElsayadHans Theodor Eich
Oct 21, 2016·The American Journal of Dermatopathology·Sergio Pina-OviedoPhyu P Aung
Jan 14, 2011·American Journal of Clinical Pathology·Claire BénetTony Petrella
Nov 18, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Michael OertelHans Theodor Eich
May 5, 2018·BMJ Case Reports·Prasanth BalasubramanianPankaj Malhotra
Aug 5, 2005·Genes, Chromosomes & Cancer·George DeebRichard T Cheney
Apr 11, 2019·JAMA Dermatology·Cynthia X WangMilan J Anadkat
Oct 30, 2009·American Journal of Clinical Pathology·Danielle M P CroninUma N Sundram
Aug 28, 2004·Periodontology 2000·Clay B WalkerPierre Baehni
Jun 20, 2015·The American Journal of Dermatopathology·Simon A RitchieAnthony A Gaspari
Jun 25, 2020·Current Oncology Reports·Richard BakstJoachim Yahalom
Dec 14, 2016·Case Reports in Medicine·Geetha NarayananLali V Soman
Jan 20, 2021·Annales de dermatologie et de vénéréologie·H MarescassierM Masson Regnault

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