A comparative study on the in vitro formation of hydroxyapatite, cytotoxicity and antibacterial activity of 58S bioactive glass substituted by Li and Sr

Materials Science & Engineering. C, Materials for Biological Applications
Amirhossein MoghanianArman Sedghi

Abstract

Lithium and strontium up to 10 mol% have been substituted for calcium in 58S bioactive glasses in order to enhance specific biological properties such as proliferation, alkaline phosphatase (ALP) activity of cells as well as antibacterial activity. In-vitro formation of hydroxyapatite was studied using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), inductively coupled plasma atomic emission spectrometry (ICP-AES) and scanning electron microscopy (SEM). Substitution of either Li or Sr for Ca in the composition had a retarding effect on the bioactivity while Li decreased and Sr increased the rate of ion release in the simulated body fluid solution. The dissolution rate showed to be inversely proportional to oxygen density of the bioactive glasses. The proposed mechanisms for the lowered bioactivity are a lower supersaturation degree for nucleation of apatite in Li substituted bioactive glasses and blocking of the active growth sites of calcium phosphate by Sr2+ in Sr substituted bioactive glasses. The proliferation rate and alkaline phosphate activity of osteoblast cell line MC3T3-E1 treated with Li and Sr bioactive glasses were studied. 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) a...Continue Reading

Citations

Apr 4, 2019·Advanced Healthcare Materials·Henri GranelYohann Wittrant
Dec 19, 2019·Journal of Tissue Engineering and Regenerative Medicine·Amirhossein MoghanianNasim Annabi
May 26, 2020·Dental Materials Journal·Huanhuan JiangLiqin Tang
Dec 5, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Areg E OmarMohammad M Farag
Jan 2, 2021·Journal of Dentistry·Humberto Palza CorderoPatricia Palma Fluxá
Jun 28, 2019·Biomacromolecules·Ophélie GourgasMarta Cerruti
Nov 16, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Ophélie GourgasMarta Cerruti
Sep 2, 2021·Journal of Applied Biomaterials & Functional Materials·Rui ZhaoQizhi Wang

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