PMID: 6988106Jan 1, 1980Paper

A comparative trial of flunisolide and beclomethasone dipropionate in the treatment of perennial allergic rhinitis

Clinical Allergy
J N SahayC Engler

Abstract

An open, parallel comparison of flunisolide and beclomethasone dipropionate nasal sprays is described. Sixty patients entered the study of whom fifty-six completed the full 4 weeks' therapy. The dosage of flunisolide was two actuations (25 micrograms/actuation) into each nostril twice a day (total 200 micrograms). The dosage of beclomethasone dipropionate was one actuation (50 micrograms) in each nostril four times a day (total 400 micrograms). Both drugs produced statistically significant improvements compared with admission values in sneezing, stuffiness, runny nose, nose blowing and post-nasal drip. Both drug significantly decreased the interference by symptoms with routine life and sleep. At the end of the trial both treatment groups showed total or good control of symptoms in the majority of patients. No statistically significant difference was shown between the effects of the two drugs. Side-effects did not cause withdrawal from the trial in any patient and were mostly confined to minor headache and nose and throat complaints. In neither treatment group was there any evidence of adrenal suppression or growths of Candida from nasal swabs.

References

Apr 1, 1977·The Journal of Allergy and Clinical Immunology·J K KammermeyerH B Richerson
Nov 1, 1976·The Journal of Allergy and Clinical Immunology·P C TurkeltaubS Crepea
Jan 30, 1965·Lancet·J B WOODJ LANDON

Citations

Oct 1, 1993·Allergy·N Mygind
Oct 1, 1982·Clinical Otolaryngology and Allied Sciences·N Mygind
Nov 1, 1984·The Journal of Pediatrics·M L Soderberg-Warner
Sep 12, 1998·Primary Care·D Weldon
Jan 1, 1989·Pharmacotherapy·M E Dushay, C E Johnson

Related Concepts

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Rhinitis, Allergic, Perennial
Hypersensitivity Skin Testing

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