PMID: 9184950May 1, 1997Paper

A comparative trial of labor induction with misoprostol versus oxytocin

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
F Escudero, H Contreras

Abstract

To determine the efficacy and safety of intravaginal misoprostol compared with intravenous oxytocin in cervical ripening and labor induction. The study was carried out at the Department of Obstetrics and Gynecology at the Hospital Loayza, Lima, Peru. The sample included 123 pregnant women with any indication for labor induction. The study was prospective and randomized. We compared the effect of 50 micrograms of intravaginal misoprostol administered every 4 h up to 600 micrograms with that observed using the standard protocol of oxytocin by continuous infusion. 57 patients with misoprostol (group 1) and 63 with oxytocin (group 2) were enrolled. Delivery occurred in 45 patients (78.9%) in group 1 and in 37 (58.7%) in group 2 (P < 0.017). Complications including tachysystole, uterine hypertony and hyperstimulation were higher in group 1, 21.1% than in group 2, 7.9% (P < 0.04). The incidence of cesarean section in both groups was similar to the overall incidence in our center. No differences were observed between groups in perinatal and postpartum adverse outcomes. The interval from start of induction to vaginal delivery was significantly shorter in the oxytocin group (8.4 +/- 4.1 vs. 11.3 +/- 6.9 h, P < 0.005). Intravaginal admin...Continue Reading

References

Feb 1, 1987·American Journal of Obstetrics and Gynecology·T MainprizeD Persaud
Aug 1, 1994·American Journal of Obstetrics and Gynecology·A BugalhoA Faáundes
Jul 1, 1993·British Journal of Obstetrics and Gynaecology·H M FletcherD Brown

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Citations

Mar 22, 2012·Archives of Gynecology and Obstetrics·Mohamed KandilAlaa Masood
Oct 13, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H G SahinM Guvercinci
Jan 30, 2002·Obstetrics and Gynecology·Kelly BlanchardCaitlin Shannon
Sep 13, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M Mutlu MeydanliAli Haberal
Apr 23, 2002·Acta Obstetricia Et Gynecologica Scandinavica·H Guler SahinMustafa Kocer
Aug 19, 2000·Clinical Obstetrics and Gynecology·L Sanchez-Ramos, A M Kaunitz
Aug 24, 1999·British Journal of Obstetrics and Gynaecology·G J HofmeyrZ Alfirevic
Mar 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Z TabasiM Mahdian
Jan 13, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sahin ZeterogluHuseyin A Sahin
Sep 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sahin ZeterogluHuseyin Avni Sahin
Sep 16, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·E M ElhassanI Adam
Sep 6, 2008·American Journal of Obstetrics and Gynecology·Linda FonsecaEdward R Yeomans
Dec 26, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H L KidantoJ van Roosmalen
Aug 16, 2003·São Paulo Medical Journal = Revista Paulista De Medicina·Márcia Maria Auxiliadora de Aquino, José Guilherme Cecatti
Oct 12, 2010·The Cochrane Database of Systematic Reviews·G Justus HofmeyrCynthia Pileggi
May 26, 2017·SAGE Open Medicine·Trishna AcharyaRadha Acharya

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