A comparison among the growth hormone-lowering effects in acromegaly of the somatostatin analog SMS 201-995, bromocriptine, and the combination of both drugs

The Journal of Clinical Endocrinology and Metabolism
Steven W J LambertsE Del Pozo

Abstract

The acute GH inhibitory effects of 50 micrograms SMS 201-995, a somatostatin analog, and 2.5 mg bromocriptine were compared in 17 acromegalic patients. SMS 201-995 suppressed plasma GH levels after 2-6 h to 5 micrograms/liter or less in 10 of these 17 patients, while bromocriptine did the same in only 5 of them. There was much variation in the responsiveness to both drugs in these patients, but the GH-lowering effect of 50 micrograms SMS 201-995 was significantly greater than that of 2.5 mg bromocriptine. SMS 201-995 and bromocriptine together significantly suppressed plasma GH levels in 2 of 3 acromegalic patients who were insensitive to both compounds when tested separately. We conclude that most acromegalic patients respond better to SMS 201-995, while a few patients are more sensitive to the GH-lowering effect of bromocriptine. In addition, the combination of SMS 201-995 and bromocriptine can be of value in a few acromegalic patients who do not respond to either drug alone.

Citations

Dec 29, 2007·Reviews in Endocrine & Metabolic Disorders·John D Carmichael, Vivien S Bonert
Apr 9, 2002·Current Neurology and Neuroscience Reports·Paul L PenarAfshin Salsali
May 16, 2009·Advances in Therapy·Sampath Satish KumarRobert D Murray
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·C B Newman
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·A Ben-Shlomo, S Melmed
Mar 1, 1990·Baillière's Clinical Endocrinology and Metabolism·S W LambertsJ C Reubi
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Pamela U Freda
Apr 5, 1990·The New England Journal of Medicine·S Melmed
Mar 21, 1991·The New England Journal of Medicine·A Klibanski, N T Zervas
Jan 25, 1996·The New England Journal of Medicine·S W LambertsL J Hofland
Sep 14, 2000·Australian and New Zealand Journal of Medicine·J K LiC S Cockram
Sep 13, 2002·Australian Veterinary Journal·L A AbrahamS A Holloway
Jul 1, 1990·Journal of Veterinary Internal Medicine·M E PetersonC D Lothrop
Aug 1, 1987·British Medical Journal·S R Bloom, J M Polak
Dec 11, 1993·BMJ : British Medical Journal·J A Wass
Sep 13, 2000·Drugs & Aging·D FeroneS W Lamberts
Apr 7, 2007·European Journal of Endocrinology·Annamaria ColaoGaetano Lombardi
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A ColaoL Annunziato
Jul 23, 2013·Frontiers in Neuroendocrinology·Marily Theodoropoulou, Günter K Stalla
Sep 27, 2003·Clinical Endocrinology·Roberto BaldelliGuido Tamburrano
Jun 1, 1989·Cancer Treatment Reviews·H ParmarS L Lightman
Jan 1, 1990·Trends in Endocrinology and Metabolism : TEM·S W LambertsJ C Reubi
Jun 1, 1989·Australian and New Zealand Journal of Medicine·K S LamR T Yeung
Nov 8, 2011·Molecular and Cellular Endocrinology·Fumio OtsukaHirofumi Makino
Aug 1, 1987·European Journal of Clinical Investigation·S W LambertsJ C Reubi
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Song-Guang RenShlomo Melmed
Mar 25, 1999·Journal of Endocrinological Investigation·A ColaoG Lombardi
Jul 1, 2016·Expert Review of Endocrinology & Metabolism·Katharina Schilbach, Jochen Schopohl
Jun 2, 2018·International Journal of Endocrinology·Ming ShenZhaoyun Zhang
Jan 1, 1988·Clinical Endocrinology·C DieguezM F Scanlon
Jun 1, 1988·Journal of Endocrinological Investigation·G DelitalaR Virdis
Oct 1, 1988·Drug Intelligence & Clinical Pharmacy·J M Rosenberg
Jun 29, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Maria Fleseriu
Jan 16, 2020·Archives of Endocrinology and Metabolism·Eva C CoopmansSebastian J C M M Neggers

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