Abstract
The management of chronic hepatitis B patients is not well characterized in real-world practice. We compared baseline characteristics of CHB patients on entecavir, the frequency of on-treatment monitoring, and the effectiveness of ETV treatment between academic and community practices. Treatment-naïve CHB patients ≥18 years old, treated with ETV for ≥12 months from 2005 to 2013, in 26 community and academic practices throughout the USA were retrospectively evaluated. Of 841 patients enrolled, 658 (65% male, 83% Asian, median age 47, 9% with cirrhosis) met inclusion criteria. Half of the patients (52%) were from community practices. A lower percentage of patients in community practices had cirrhosis or liver cancer (5 vs. 14%). Community practices more often treated patients with baseline ALT < 2 × ULN. Over a median follow-up of 4 years, community practices were more likely to discontinue ETV with less frequent laboratory monitoring compared to academic practices. The 5-year cumulative probability of ALT normalization was greater among patients treated in community practices (70 vs. 50%, p < 0.001), but the 5-year cumulative probability of undetectable HBV DNA was lower (45 vs. 70%, p < 0.001) than those treated in academic pra...Continue Reading
References
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeTeresa L Wright
Oct 12, 2007·Journal of Hepatology·Michelle LaiNezam H Afdhal
Oct 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeHillel Tobias
Dec 5, 2008·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Jan 6, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ting-Tsung ChangUchenna Iloeje
Jan 11, 2011·Journal of Gastroenterology and Hepatology·Myron John TongLawrence Mitchell Blatt
Sep 22, 2011·Digestive Diseases and Sciences·Myron J TongTruong-Sinh Leduc
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kris V KowdleyCarol L Brosgart
Apr 3, 2012·Digestive Diseases and Sciences·Sue ZhangMindie H Nguyen
May 11, 2012·Journal of Viral Hepatitis·S Pol, P Lampertico
Oct 24, 2012·Journal of Clinical Gastroenterology·Nghiem B HaMindie H Nguyen
Oct 15, 2013·Digestive Diseases and Sciences·Kevin C KuMindie H Nguyen
Dec 18, 2013·Antiviral Therapy·Victoria AramaUNKNOWN AI463-121 European Longitudinal Chronic Hepatitis B Study Group
Mar 4, 2014·Journal of Clinical Gastroenterology·Edoardo G GianniniUNKNOWN Ligurian Hepatitis B Virus Study Group
Apr 15, 2014·Digestive Diseases and Sciences·Monika SarkarM Michele Manos
Jul 26, 2014·Digestive Diseases and Sciences·Lily H KimMindie H Nguyen
Jan 30, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeong Won JangKwang-Hyub Han
May 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dong Hyun SinnSeung Woon Paik
Aug 2, 2015·Lancet·Aparna SchweitzerJördis J Ott
Oct 30, 2015·Alimentary Pharmacology & Therapeutics·J AhnA S Lok
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultJohn B Wong