A Comparison Between Community and Academic Practices in the USA in the Management of Chronic Hepatitis B Patients Receiving Entecavir: Results of the ENUMERATE Study

Digestive Diseases and Sciences
Hannah M LeeAnna S Lok

Abstract

The management of chronic hepatitis B patients is not well characterized in real-world practice. We compared baseline characteristics of CHB patients on entecavir, the frequency of on-treatment monitoring, and the effectiveness of ETV treatment between academic and community practices. Treatment-naïve CHB patients ≥18 years old, treated with ETV for ≥12 months from 2005 to 2013, in 26 community and academic practices throughout the USA were retrospectively evaluated. Of 841 patients enrolled, 658 (65% male, 83% Asian, median age 47, 9% with cirrhosis) met inclusion criteria. Half of the patients (52%) were from community practices. A lower percentage of patients in community practices had cirrhosis or liver cancer (5 vs. 14%). Community practices more often treated patients with baseline ALT < 2 × ULN. Over a median follow-up of 4 years, community practices were more likely to discontinue ETV with less frequent laboratory monitoring compared to academic practices. The 5-year cumulative probability of ALT normalization was greater among patients treated in community practices (70 vs. 50%, p < 0.001), but the 5-year cumulative probability of undetectable HBV DNA was lower (45 vs. 70%, p < 0.001) than those treated in academic pra...Continue Reading

References

Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeTeresa L Wright
Oct 12, 2007·Journal of Hepatology·Michelle LaiNezam H Afdhal
Oct 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeHillel Tobias
Dec 5, 2008·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Jan 6, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ting-Tsung ChangUchenna Iloeje
Jan 11, 2011·Journal of Gastroenterology and Hepatology·Myron John TongLawrence Mitchell Blatt
Sep 22, 2011·Digestive Diseases and Sciences·Myron J TongTruong-Sinh Leduc
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kris V KowdleyCarol L Brosgart
Oct 24, 2012·Journal of Clinical Gastroenterology·Nghiem B HaMindie H Nguyen
Oct 15, 2013·Digestive Diseases and Sciences·Kevin C KuMindie H Nguyen
Dec 18, 2013·Antiviral Therapy·Victoria AramaUNKNOWN AI463-121 European Longitudinal Chronic Hepatitis B Study Group
Mar 4, 2014·Journal of Clinical Gastroenterology·Edoardo G GianniniUNKNOWN Ligurian Hepatitis B Virus Study Group
Apr 15, 2014·Digestive Diseases and Sciences·Monika SarkarM Michele Manos
Jul 26, 2014·Digestive Diseases and Sciences·Lily H KimMindie H Nguyen
Jan 30, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeong Won JangKwang-Hyub Han
May 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dong Hyun SinnSeung Woon Paik
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultJohn B Wong

❮ Previous
Next ❯

Citations

Nov 6, 2018·Digestive Diseases and Sciences·Christina Pham, Alexander Kuo
Aug 8, 2020·Abdominal Radiology·Helena B Thomaides-BrearsCarlos Duncker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.