A comparison between different prediction models for invasive breast cancer occurrence in the French E3N cohort

Breast Cancer Research and Treatment
Laureen DartoisGuy Fagherazzi

Abstract

Breast cancer remains a global health concern with a lack of high discriminating prediction models. The k-nearest-neighbor algorithm (kNN) estimates individual risks using an intuitive tool. This study compares the performances of this approach with the Cox and the Gail models for the 5-year breast cancer risk prediction. The study included 64,995 women from the French E3N prospective cohort. The sample was divided into a learning (N = 51,821) series to learn the models using fivefold cross-validation and a validation (N = 13,174) series to evaluate them. The area under the receiver operating characteristic curve (AUC) and the expected over observed number of cases (E/O) ratio were estimated. In the two series, 393 and 78 premenopausal and 537 and 98 postmenopausal breast cancers were diagnosed. The discrimination values of the best combinations of predictors obtained from cross-validation ranged from 0.59 to 0.60. In the validation series, the AUC values in premenopausal and postmenopausal women were 0.583 [0.520; 0.646] and 0.621 [0.563; 0.679] using the kNN and 0.565 [0.500; 0.631] and 0.617 [0.561; 0.673] using the Cox model. The E/O ratios were 1.26 and 1.28 in premenopausal women and 1.44 and 1.40 in postmenopausal women....Continue Reading

References

Jul 1, 1976·The American Journal of Cardiology·W B KannelT Gordon
Jan 1, 1990·Journal of Clinical Epidemiology·C BouchardyC Hill
Jul 1, 1995·Annals of Epidemiology·F Clavel-ChapelonR Renaud
Mar 20, 1996·Journal of the National Cancer Institute·B Rosner, G A Colditz
Jan 1, 1997·International Journal of Epidemiology·M J van LiereS Villeminot
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Laufey TryggvadóttirTrausti Sigurvinsson
Nov 1, 2002·Breast Cancer Research and Treatment·William F AndersonOtis W Brawley
Dec 19, 2002·Journal of the American Dietetic Association·B TehardF Clavel-Chapelon
Jan 15, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kimiko UedaAkira Oshima
Feb 5, 2004·Journal of the National Cancer Institute·Graham A ColditzSusan E Hankinson
Apr 2, 2004·Statistics in Medicine·Jonathan TyrerJack Cuzick
May 29, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P BoyleC Robertson
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Agnès FournierFrançoise Clavel-Chapelon
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jeffrey A TiceMargaret R Wrensch
May 19, 2005·Journal of the National Cancer Institute·Andrew N FreedmanRuth M Pfeiffer
Nov 2, 2005·Breast Cancer Research and Treatment·Jeffrey A TiceKarla Kerlikowske
Dec 2, 2005·Breast Cancer Research and Treatment·Jan NovotnyMiloslava Skovajsova
Jun 7, 2006·British Journal of Cancer·M García-ClosasM E Sherman
Sep 7, 2006·Journal of the National Cancer Institute·William E BarlowKarla Kerlikowske
Nov 15, 2007·Journal of the National Cancer Institute·Rowan T ChlebowskiUNKNOWN Women's Health Initiative Investigators
Nov 29, 2007·Journal of the National Cancer Institute·Mitchell H GailLeslie Bernstein
May 30, 2009·BMJ : British Medical Journal·Douglas G AltmanKarel G M Moons
Oct 31, 2009·American Journal of Epidemiology·Nancy R CookGraham A Colditz
Mar 20, 2010·The New England Journal of Medicine·Sholom WacholderDavid J Hunter
Apr 30, 2010·Journal of the National Cancer Institute·Eitan AmirD Gareth Evans
Dec 15, 2010·Future Oncology·Ismail Jatoi, William F Anderson
Jan 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Moniek van ZitterenA Cecile J W Janssens
Mar 24, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G FagherazziF Clavel-Chapelon
May 13, 2011·Journal of the National Cancer Institute·Rayna K MatsunoMitchell H Gail
Jun 28, 2011·Journal of the National Cancer Institute·Elisabetta PetracciMitchell H Gail
Nov 1, 2011·Breast Cancer Research and Treatment·Catherine MeadsRichard D Riley
Nov 15, 2011·Breast Cancer Research and Treatment·Thunyarat AnothaisintaweeAmmarin Thakkinstian
Feb 5, 2013·Breast Cancer Research and Treatment·Roberto Pastor-BarriusoMarina Pollán
Mar 19, 2013·BMC Medical Research Methodology·Patrick Royston, Douglas G Altman
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kala VisvanathanScott M Lippman

❮ Previous
Next ❯

Citations

Jul 31, 2016·Bulletin du cancer·Suzette DelalogeUNKNOWN Intergroupe national de recherche sur le cancer du sein Unicancer (UCBG)
Sep 27, 2020·Bulletin du cancer·Catherine UzanSerge Uzan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.