A comparison between heparin and low-dose aspirin as adjunctive therapy with tissue plasminogen activator for acute myocardial infarction. Heparin-Aspirin Reperfusion Trial (HART) Investigators

The New England Journal of Medicine
J HsiaA M Ross

Abstract

We report the results of the Heparin-Aspirin Reperfusion Trial, a collaborative study comparing early intravenous heparin with oral aspirin as adjunctive treatment when recombinant tissue plasminogen activator (rt-PA) is used for coronary thrombolysis during acute myocardial infarction. Two hundred five patients were randomly assigned to receive either immediate and then continuous intravenous heparin (starting with a 5000-unit bolus; n = 106) or immediate and then daily oral aspirin (80 mg; n = 99) together with rt-PA (100 mg intravenously over a six-hour period) initiated within six hours of the onset of symptoms. We evaluated the patency of the infarct-related artery by angiography 7 to 24 hours after beginning rt-PA infusion, the frequency of reocclusion of the artery by repeat angiography on day 7, and ischemic or hemorrhagic complications during the hospital stay. At the time of the first angiogram, 82 percent of the infarct-related arteries in the patients assigned to heparin were patent, as compared with only 52 percent in the aspirin group (P less than 0.0001). Of the initially patent vessels, 88 percent remained patent after seven days in the heparin group, as compared with 95 percent in the aspirin group (P not signi...Continue Reading

References

Jun 1, 1989·Journal of the American College of Cardiology·P W ArmstrongC D Morgan
Mar 1, 1988·The American Journal of Cardiology·D G MatheyW Bleifeld
Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Jun 1, 1982·The Journal of Clinical Investigation·P PatrignaniC Patrono

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Citations

Jul 1, 1996·Catheterization and Cardiovascular Diagnosis·R L QuigleyM H Salinger
Jan 1, 1991·Clinical Cardiology·J H Vogel
Nov 1, 1992·Clinical Cardiology·P Jain, S C Vlay
Apr 1, 1993·Clinical Cardiology·N W ShammasP Fitzpatrick
Nov 1, 1995·Journal of Clinical Pharmacology·M Gibaldi, A K Wittkowsky
Apr 1, 1992·Cardiovascular Drugs and Therapy·M Verstraete
Jan 1, 1995·Journal of Thrombosis and Thrombolysis·H D White, S Yusuf
Oct 1, 1994·Annals of Hematology·D C Gulba, R Dechend
Jan 13, 2006·Current Treatment Options in Cardiovascular Medicine·Michelle O'Donoghue, Marc S Sabatine
Nov 15, 1994·The American Journal of Cardiology·J L Anderson, L A Karagounis
May 16, 1992·Lancet·B E Sobel, D Collen
Nov 15, 1991·Journal of the American College of Cardiology·E S Monrad
Jul 1, 1992·Journal of the American College of Cardiology·F A NicoliniC Mattsson
Apr 1, 1992·Journal of the American College of Cardiology·P R EisenbergA S Jaffe
Jul 1, 1993·Journal of the American College of Cardiology·N A PragerD R Abendschein
Jun 1, 1995·Journal of the American College of Cardiology·C J O'DonnellC H Hennekens
Nov 15, 1995·Journal of the American College of Cardiology·M A BrouwerF W Verheugt
Mar 15, 1996·Journal of the American College of Cardiology·F W VerheugtM J Van Eenige
Jan 1, 1993·The Journal of Emergency Medicine·S H ThomasE J Allison
Jan 1, 1996·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B K Metz, E J Topol
Sep 29, 2000·The American Journal of Cardiology·M CohenD Radley
Aug 1, 1994·Mayo Clinic Proceedings·G S Reeder, S L Kopecky
Dec 24, 1997·Progress in Cardiovascular Diseases·A E Schussheim, V Fuster
May 23, 1997·International Journal of Cardiology·M S GotsmanA T Weiss
Feb 1, 1993·Annals of Emergency Medicine·M S EisenbergW D Weaver
Mar 1, 1992·Journal of the American College of Cardiology·S RouxE Lüdin

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