A comparison between the blocking actions of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) and its N-methyl quaternary analogue (AH 5954)

British Journal of Pharmacology
I G Marshall


1. The neuromuscular blocking activities of AH 5183 (2-(4-phenylpiperidino) cyclohexanol) and its N-methyl quaternary analogue (AH 5954) were compared in rapidly stimulated nerve-skeletal muscle preparations of the rat, chicken and cat.2. The evidence indicated that in isolated preparations the neuromuscular block produced by both AH 5183 and AH 5954 was primarily pre-junctional in origin. That produced by AH 5954 was readily reversible either by washing the tissue or by reducing the stimulation frequency, whereas that produced by AH 5183 was difficult to reverse in these ways.3. Low doses of AH 5954 sensitized the rat hemidiaphragm preparation to the neuromuscular blocking action of choline. The neuromuscular block produced by choline was reversible by tetraethylammonium but not by neostigmine. This suggested that the blocking action of choline is at least partly pre-junctional in nature.4. In anaesthetized cats AH 5954 possessed a biphasic neuromuscular blocking action. The initial phase was rapid in onset, suggestive of a post-junctional action, whereas the second phase was prolonged and reversible by choline, suggestive of a prejunctional inhibitory action on the choline transport mechanism. AH 5183 produced no initial bloc...Continue Reading


Oct 1, 1969·European Journal of Pharmacology·R T BrittainM B Tyers
Sep 1, 1968·The Journal of Pharmacy and Pharmacology·H DowdB M Tracy
Jul 1, 1969·British Journal of Pharmacology·K Martin
May 1, 1969·Journal of Pharmaceutical Sciences·M S Ghouri, T J Haley
Feb 1, 1970·British Journal of Pharmacology·W C Bowman, M T Hall
May 1, 1970·British Journal of Pharmacology·I G Marshall
Feb 1, 1970·Journal of Neurochemistry·B A Hemsworth, J C Smith
Mar 1, 1968·British Journal of Pharmacology and Chemotherapy·S E Freeman
Feb 1, 1968·European Journal of Pharmacology·I G Marshall
Sep 1, 1968·British Journal of Pharmacology·I G Marshall
Oct 1, 1965·British Journal of Pharmacology and Chemotherapy·W C Bowman, B A Hemsworth
Sep 1, 1960·British Journal of Pharmacology and Chemotherapy·B L GINSBORG, J WARRINER
Jan 1, 1960·International Review of Neurobiology·F W SCHUELER
Oct 1, 1961·British Journal of Pharmacology and Chemotherapy·W C BOWMAN, M J RAND
Sep 18, 1930·The Journal of Physiology·B Finkleman
Mar 1, 1946·British Journal of Pharmacology and Chemotherapy·E BULBRING

❮ Previous
Next ❯


Jan 1, 1986·Pflügers Archiv : European journal of physiology·W Van der Kloot
Jul 1, 1977·European Journal of Pharmacology·J M van NuetenP A Janssen
May 1, 1995·Trends in Neurosciences·T B UsdinJ D Erickson
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M R MarienC A Altar
Jan 1, 1973·The International Journal of Neuroscience·A Gandiha, I G Marshall
Jan 1, 1991·Progress in Neurobiology·W Van der Kloot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.