A comparison between the localization of lung tumors in uranium miners and in nonminers from 1947 to 1991

Cancer
G SaccomannoJ J Bechtel

Abstract

Lung cancer was noted to be increased in cigarette smoking miners and nonminers. Carcinogen particulates deposit differentially in the central, middle, and peripheral zones of the bronchial tree depending on the size of the particle. The object of this study was to evaluate the incidence of tumors; their cell types; and the relationship of particulate size to their position in the bronchial tree. Tumor position in the bronchial tree was studied for a cohort of 467 uranium miners and 311 nonminers with lung cancer. An examination of all histologic subtypes showed that the proportion of lung cancers in the central zone was significantly greater in miners than in nonminers presumably due to the deposition of radon decay products attached to the silica dust particles. The higher percentage of central tumors in the miners was primarily due to the distribution of a greater proportion of squamous cell and small-cell tumors. The ratio of 0.75 for the central to middle and peripheral location for adenocarcinomas was much lower than for squamous cell and small-cell carcinomas with ratios of 1.4 and 7.3, respectively. In the mining cohort, there were ten times as many small-cell tumors in the central area as in the middle and peripheral r...Continue Reading

References

Jun 1, 1975·American Industrial Hygiene Association Journal·A C GeorgeR Sladowski
May 1, 1990·American Industrial Hygiene Association Journal·W J MullerP W Scherer
Apr 1, 1985·Journal of the National Cancer Institute·A H WuM C Yu
Aug 10, 1961·The New England Journal of Medicine·O AUERBACHL GARFINKEL

❮ Previous
Next ❯

Citations

Jan 18, 2003·Archives of Environmental Health·Paula L Díaz SylvesterRómulo L Cabrini
May 7, 2015·Radiation Protection Dosimetry·R Winkler-HeilL Pichelstorfer
Apr 30, 2015·Radiation Protection Dosimetry·W Hofmann, R Winkler-Heil
Nov 24, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Franz Stanzel
May 1, 2004·Photodiagnosis and Photodynamic Therapy·T A HorvathH Kato
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Charles L Sanders, Bobby R Scott
Jun 30, 2000·Journal of Occupational and Environmental Medicine·P CoccoM Dosemeci
Sep 23, 2003·Epidemiology·Michaela KreuzerH-Erich Wichmann
Sep 16, 2015·Environmental Health Perspectives·Shuguang LengSteven A Belinsky
Oct 7, 2019·Radiation and Environmental Biophysics·Péter FüriImre Balásházy
Jan 18, 2020·Radiation Protection Dosimetry·Werner Hofmann, Renate Winkler-Heil
Jul 20, 2021·Radiation Protection Dosimetry·James W MarshJohn D Harrison

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Ping JiangQian Gao
Zhongguo fei ai za zhi = Chinese journal of lung cancer
Xiaomei LiuQinghua Zhou
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Xiao-Hui RenYa-Jia Lan
© 2021 Meta ULC. All rights reserved