PMID: 602881Dec 1, 1977Paper

A comparison between the prostaglandin releasing effects of angiotensin II and angiotensin III

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Z S Ercan, R K Türker

Abstract

Angiotensin II and its natural fragment (des-aspartic acid)1-angiotensin II (angiotensin III) induced a dose-dependent contraction in the isolated rat stomach fundus strip and rat colon. 1-Acetyl-2-(8-chloro-10,11-dihydrodibenz(b,f)(1,4)oxazepine-10, carbonyl) hydrazine (SC 19220), a widely used competitive-blocker of prostaglandins and acetyl salicylic acid, a well-known inhibitor of prostaglandin biosynthesis, partially abolished the contraction induced by both peptides in the rat stomach fundus but not in the rat colon. The inhibition induced by SC 19220 and acetyl salicylic acid was found to be higher for angiotensin III than angiotensin II when the dose-response curves and equipotent concentrations of the peptides were compared before and after the drugs. These results were taken as evidence that some component of the contractile effects of angiotensin II and angiotensin III on the isolated rat stomach fundus involves the release of prostaglandins by the peptides and in this respect angiotensin III has higher potency than angiotensin II.

References

Jan 1, 1976·Prostaglandins·A BlumbergP Needleman
Feb 1, 1973·The Journal of Pharmacy and Pharmacology·E K Chong, O A Downing
Sep 1, 1973·British Journal of Pharmacology·S H FerreiraJ R Vane
Apr 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J R Blair-WestR D Wright
Sep 8, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·B Peskar, G Hertting
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Oct 1, 1964·British Journal of Pharmacology and Chemotherapy·D REGOLI, J R VANE

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Citations

Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·G J TrachteM J Peach
Aug 26, 1998·European Journal of Pharmacology·E SipahiR K Türker
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M E Elliott, T L Goodfriend
Aug 1, 1978·Archives internationales de physiologie et de biochimie·Z S ErcanM Torunoglu
Mar 15, 1980·Biochemical Pharmacology·R U SimpsonT L Goodfriend
Sep 1, 1983·Pharmacological Research Communications·G CoruzziB Starcich
Apr 1, 1989·Journal of Autonomic Pharmacology·F E LüdtkeF Schubert
Aug 12, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Guo-Du WangJackie D Wood

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