A comparison between whole mung bean and decorticated mung bean: beneficial effects on the regulation of serum glucose and lipid disorders and the gut microbiota in high-fat diet and streptozotocin-induced prediabetic mice.

Food & Function
Dianzhi HouQun Shen

Abstract

The aim of this study is to investigate the beneficial effects of whole mung bean (WMB) and decorticated mung bean (DMB) on the regulation of serum glucose and lipid disorders in high-fat diet (HFD) and streptozotocin (STZ)-induced prediabetic mice, and to further explore their gut microbiota modulatory effects. In the present study, the ability of mung bean-based diets to combat prediabetes-related metabolic disorders was determined by assessing the changes in the physiological, biochemical, and histological parameters, and the gut microbiota composition of prediabetic mice. The supplementation of both WMB and DMB can effectively alleviate HFD and STZ-induced impaired glucose tolerance (P < 0.05), which was accompanied by improvements in pancreatic β-cell damage and hepatic steatosis. However, only WMB supplementation significantly decreased the fasting blood glucose and fasting serum insulin levels by sensitizing insulin action (P < 0.05), and reduced the serum lipid profiles and glycosylated serum protein levels (P < 0.05). Furthermore, high-throughput pyrosequencing of the 16S rRNA gene revealed that WMB and DMB supplementation could prevent HFD and STZ-induced gut microbiota dysbiosis, especially for the enrichment of some...Continue Reading

References

Sep 5, 2008·Journal of Agricultural and Food Chemistry·Yang YaoGuixing Ren
Aug 10, 2011·The American Journal of Cardiology·Ralph A DeFronzo, Muhammad Abdul-Ghani
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenPaul Z Zimmet
Jun 12, 2012·Lancet·Adam G TabákMika Kivimäki
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Swee Keong YeapKamariah Long
Nov 20, 2012·Molecular Aspects of Medicine·Jian ShenLiping Zhao
Mar 22, 2013·Cellular and Molecular Life Sciences : CMLS·Francesca TurroniDouwe van Sinderen
Sep 7, 2013·Critical Reviews in Food Science and Nutrition·Muhammad AsifMian N Riaz
Nov 23, 2013·Critical Reviews in Food Science and Nutrition·Poonam SinghalPulkit Mathur
Jan 18, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C J RebelloJ W Finley
Nov 12, 2014·World Journal of Gastroenterology : WJG·Rafael TojoPatricia Ruas-Madiedo
Jan 24, 2015·Current Opinion in Biotechnology·Joël Doré, Hervé Blottière
Mar 20, 2015·World Journal of Diabetes·Nidhi Bansal
Mar 21, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zohre HashemiCatherine B Chan
Apr 30, 2016·Critical Reviews in Food Science and Nutrition·Alexander Medina-RemónRamón Estruch
May 10, 2016·Molecular Nutrition & Food Research·Pan Xi, Rui Hai Liu
Jan 6, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenlong SunYuesheng Dong
Jan 13, 2017·Public Health Nutrition·Stefano MarventanoGiuseppe Grosso
Apr 11, 2017·European Journal of Nutrition·Ian RowlandKieran Tuohy
Jan 31, 2018·Diabetologia·Kristine H AllinOluf Pedersen
Feb 2, 2018·Food Research International·Lingxiao GongBaoguo Sun
Feb 10, 2018·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wenlong SunYuesheng Dong
Mar 24, 2018·Best Practice & Research. Clinical Gastroenterology·Noora OttmanClara Belzer
Apr 14, 2018·Canadian Journal of Diabetes·UNKNOWN Diabetes Canada Clinical Practice Guidelines Expert CommitteePamela Katz
Sep 15, 2018·Current Diabetes Reports·Antonio SircanaGiovanni Musso
Feb 17, 2019·The Journal of Nutritional Biochemistry·Chrissa PetersenPon Velayutham Anandh Babu
Mar 4, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuqing ChenChao Zhao
Apr 8, 2019·Journal of Ethnopharmacology·Zhiwen ZhangZhenghong Xu

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Methods Mentioned

BETA
ELISA
electrophoresis
PCR

Software Mentioned

SPSS
UPARSE
GraphPad Prism
R
QIIME
LEfSe
Mothur

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