A comparison of a short course of single daily dosage therapy of tinidazole with metronidazole in intestinal amoebiasis

The Journal of International Medical Research
N P Misra, R C Gupta


Sixty patients with symptomatic intestinal amoebiasis were treated for 3 days with a single dose of 2 g of either tinidazole or metronidazole respectively by random order. Tinidazole cured 90% of patients (27/30) an metronidazole cured 53.3% of patients (16/30). The difference was significant (p less than 0-01). Mild side-effect were reported by 26-7% of patients (8/30) in the tinidazole group as compared to mild to moderated side-effects reported by 53.3% of patients (16/30) in the metronidazole group. The difference was statistically significant (p less than 0-05). As the average patient has only a limited understanding and toleration of extended treatment courses, the advantages of a short course employing a single daily dose are obvious. With such a regimen, tinidazole was found to be superior to metronidazole in intestinal amoebiasis.


Jun 1, 1972·Annals of Tropical Medicine and Parasitology·D R O'Holohan, J Hugoe-Matthews
Feb 1, 1956·Journal of Clinical Pathology·D S RIDLEY, B C HAWGOOD

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Entamoebiasis, Intestinal
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Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.