A comparison of acute stress paradigms: hormonal responses and hypothalamic serotonin

Physiology & Behavior
J ParisC L Bethea

Abstract

The effects of stress on plasma renin activity (PRA), plasma prolactin and corticosterone levels, and hypothalamic 5-HT and 5-HIAA concentrations were investigated using a 3 and 12 min conditioned fear (CER) paradigm; 20 min immobilization; 20 min exposure to shallow or deep cold water; 2, 12 and 22 min of intermittent footshock with or without 20 min recovery; and, a 3 min CER with 0, 10, 30 and 60 min recovery. PRA was increased by all the stressors, except shallow cold water, reaching a maximum after 12 min and returning to control values within 10-20 min post-stress. Prolactin levels also were increased by all the stressors, except shallow and deep cold water. Prolactin levels were maximal after 12 min and returned to baseline within 20-60 min post-stress, depending on the stressor. Corticosterone levels were elevated by all the stressors, but not as rapidly as PRA or prolactin, reaching a maximum after about 20 min and returning to baseline concentrations within 30-60 min post-stress. None of the stressors produced significant changes in hypothalamic 5-HT and 5-HIAA concentrations.

References

Sep 10, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bastien LlamasMarie-Pierre Moisan
Aug 1, 1989·Pharmacology, Biochemistry, and Behavior·A PłaźnikW Kostowski
Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·C R Prince, H Anisman
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·R J HandaS A Lorens
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, L D Van de Kar
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·T J ConnorB E Leonard
Mar 13, 1999·Journal of Ethnopharmacology·R Archana, A Namasivayam
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·L D Van de Kar
Jan 27, 2015·Psychoneuroendocrinology·Rubia de Souza ArminiLuiz Carlos Schenberg
Jan 12, 1999·Frontiers in Neuroendocrinology·L D Van de Kar, M L Blair
Nov 6, 2008·Psychological Reports·Salvatore P Insana, Janie H Wilson
Jul 29, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Miriam B VirgoliniDeborah A Cory-Slechta

Citations

Jan 22, 1979·Life Sciences·J P AdvisJ Meites
Oct 7, 1985·Life Sciences·J H UrbanM S Brownfield
Oct 8, 1984·Brain Research·L D Van de KarC L Bethea
May 1, 1980·Neuroendocrinology·R H LenoxJ L Meyerhoff
Mar 1, 1984·The International Journal of Neuroscience·J S Richardson
Aug 1, 1980·Neuroendocrinology·R W Fuller, H D Snoddy
Sep 1, 1984·Experimental Neurology·S FeldmanJ Weidenfeld

Related Concepts

PRL
Corticosterone Assay
Swimming
Cold Temperature
Serotonin Measurement
August Rats
Serotonin
Organum Vasculosum Laminae Terminalis
Fear (Mental Process)
PRL gene

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.