A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits

Journal of Neurosurgery. Spine
D O OkonkwoJohn A Kern

Abstract

Steroid agents remain the lone pharmacological treatment in widespread use for acute spinal cord injury (SCI), although their utility remains in dispute in the neurotrauma literature. Adenosine A2A receptor activation with ATL-146e, a selective A2A agonist, has shown potential benefit in treating SCI; however, it has not been compared with the gold standard, methylprednisolone. The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI. New Zealand White rabbits sustained SCI or sham injury via the Allen weight-drop technique. Ten minutes postinjury, animals received ATL-146e (ATL group, 0.06 microg/kg/min intravenously for 3 hours), methylprednisolone (steroid group, 30 mg/kg intravenously), or saline (trauma control group). Hindlimb motor function was recorded every 12 hours using the Tarlov motor grading scale (0, paralysis-5, normal hop). At 48 hours, fixed spinal cord tissue was evaluated for neuronal viability. Hindlimb motor function in animals treated with ATL-146e was equivalent to that of sham-injured animals and was significantly better than that of trauma control animals at all time points and that of steroid-treated ani...Continue Reading

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Citations

Jan 10, 2016·Brain Research·Cheng-Chang Yang, I-Ming Jou
Dec 21, 2006·ChemMedChem·Gloria CristalliRosaria Volpini
Nov 25, 2014·Nature Nanotechnology·Alice GaudinPatrick Couvreur
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Mar 19, 2009·Alternatives to Laboratory Animals : ATLA·Aysha Z AkhtarChad B Sandusky
Apr 12, 2011·Reviews in the Neurosciences·Shuang-Shuang Dai, Yuan-Guo Zhou

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