PMID: 8973228Dec 7, 1996Paper

A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial

BMJ : British Medical Journal
D G JulianS J Pocock

Abstract

To compare aspirin with anticoagulation with regard to risk of cardiac death and reinfarction in patients who received anistreplase thrombolysis for myocardial infarction. A multicentre unblinded randomised clinical trial. 38 hospitals in six countries. 1036 patients who had been treated with anistreplase for myocardial infarction were randomly assigned to either aspirin (150 mg daily) or anticoagulation (intravenous heparin followed by warfarin or other oral anticoagulant). The trial was stopped earlier than originally intended because of the slowing rate of recruitment. Cardiac death or recurrent myocardial infarction at 30 days. After 30 days cardiac death or reinfarction, occurred in 11.0% (57/517) of the patients treated with anticoagulation and 11.2% (58/519) of the patients treated with aspirin (odds ratio 1.02, 95% confidence interval 0.69 to 1.50, P = 0.92). Corresponding findings at three months were 13.2% (68/517) and 12.1% (63/519) (0.91, 0.63 to 1.32, P = 0.67). Patients receiving anticoagulation were more likely than patients receiving aspirin to have had severe bleeding or a stroke by three months (3.9% v 1.7% (0.44, 0.20 to 0.97, P = 0.04)). No evidence of a difference in the incidence of cardiac events was foun...Continue Reading

Citations

Oct 1, 2009·Chemico-biological Interactions·Jong-Il ChoiJu-Woon Lee
Sep 27, 2002·The New England Journal of Medicine·Mette HurlenHarald Arnesen
Mar 3, 2010·The American Journal of Medicine·Salman A HaqSorin J Brener
Apr 14, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan LiYan Chai
Oct 20, 2012·Biomedical Chromatography : BMC·D Vijaya BharathiV Venkateswarlu
Sep 4, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Nooshin AbdollahpourJamshidkhan Chamani
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Yongling DingJun Yan
Jul 18, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·R AltmanA Scazziota
Dec 6, 2017·Therapeutic Advances in Hematology·Jae Youn MoonDominick J Angiolillo
Jan 26, 2011·Circulation·Marc Fisher, Joseph Loscalzo
Jan 26, 2011·Stroke; a Journal of Cerebral Circulation·Marc Fisher, Joseph Loscalzo
Nov 16, 2016·Anesthesiology and Pain Medicine·Maryam SoleimanpourSeyed Moayed Alavian
Dec 26, 2018·Expert Opinion on Investigational Drugs·Srikanth YandrapalliWilbert S Aronow
Jan 13, 2006·European Heart Journal·S E HustedA Kher
Nov 24, 1999·The Medical Journal of Australia·R E Peverill

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