PMID: 9547902Apr 21, 1998Paper

A comparison of automated fructosamine and HbA1c methods for monitoring diabetes in pregnancy

Annals of Clinical Biochemistry
D M KennedyP G Hill

Abstract

Two automated methods for measuring fructosamine (Test Plus and the original fructosamine assay) and glycated haemoglobin (Tina-quant immunoassay) were compared to determine which is the best index of blood glucose control during pregnancy. Thirteen women with type 1 diabetes were studied, with four-weekly measurements of HbA1c and fructosamine Test Plus using a Hitachi 911 analyser and fructosamine measured using an Olympus AU800 analyser. HbA1c correlated better (r = 0.573) with mean blood glucose (MBG) concentration than did fructosamine Test Plus (r = 0.347), even after correction for total protein concentration (r = 0.463), while there was no significant correlation with the original fructosamine method (r = 0.201). HbA1c correlated better with fasting/pre-prandial MBG concentrations, whereas fructosamine Test Plus correlated better with post-prandial MBG concentrations. Fructosamine Test Plus decreased with gestational age, and correlated with albumin and total protein concentrations, whereas HbA1c did not change with gestational age. Thus, HbA1c and fructosamine Test Plus were found to be useful in verifying home blood glucose measurements in diabetic pregnancy, with HbA1c being the best predictor of MBG concentration.

References

Sep 1, 1992·Annals of Clinical Biochemistry·S J Standing, R P Taylor
Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·H R HenrichsE Vorberg
May 1, 1991·Annals of Clinical Biochemistry·D H Schlebusch
Jun 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·D R Hadden
May 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·M I Drury
May 1, 1987·American Journal of Obstetrics and Gynecology·M B LandonE K Main
Nov 1, 1986·Annals of Clinical Biochemistry·M P van Dieijen-VisserP J Brombacher
Jan 15, 1972·American Journal of Obstetrics and Gynecology·K Karlsson, I Kjellmer
Jan 1, 1984·Annals of Clinical Biochemistry·K Miedema, T Casparie
Aug 1, 1984·The American Journal of Medicine·R S MazzeW Lopatin
May 1, 1994·Annals of Clinical Biochemistry·S Palfrey, M Labib
Jan 1, 1994·Annual Review of Medicine·T A Buchanan, J L Kitzmiller
Mar 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·V J ParfittM Hartog

❮ Previous
Next ❯

Citations

Aug 31, 2002·Diabetes/metabolism Research and Reviews·Philip HomeUNKNOWN Worldwide Initiative for Diabetes Education (WorldWIDE)
Nov 6, 2014·Arquivos brasileiros de endocrinologia e metabologia·Alina Coutinho Rodrigues Feitosa, Flávio Silva Andrade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.