A comparison of basal and agonist-stimulated release of endothelium-derived relaxing factor from different arteries.

British Journal of Pharmacology
M I ChristieM J Lewis

Abstract

1. The release of endothelium-derived relaxing factor (EDRF) from rabbit aorta and pig coronary artery vessels in response to acetylcholine (ACh), substance P (SP) and the calcium ionophore A23187 has been studied by means of a bioassay cascade system. 2. A technique is described which allows the quantification of EDRF release rates from vessels of different sizes, perfused at different flow rates and with different donor-recipient transient times. 3. Rabbit aorta and pig coronary arteries, perfused at flow rates which equalize endothelial shear stress, released EDRF at a similar basal rate. 4. In response to ACh, rabbit aortic endothelium released EDRF at a significantly greater maximum rate than pig coronary artery endothelium. 5. In response to SP, both endothelium types released EDRF; SP was a significantly more potent agonist in pig coronary artery than in rabbit aorta, but maximum SP-induced EDRF release from rabbit aorta was twice that of pig coronary artery. 6. These data indicate that different endothelium types can release EDRF at widely different rates, according to the agonist used, and that the previously obtained lack of relaxant response to ACh in pig coronary artery was due to a lack of EDRF release rather than ...Continue Reading

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Citations

Mar 1, 1996·Cardiovascular Drugs and Therapy·G BerkenboomJ Fontaine
Mar 28, 2008·Purinergic Signalling·T Forrester
Sep 17, 1991·European Journal of Pharmacology·M I Christie, M J Lewis
Mar 1, 1996·International Journal of Cardiology·D T KremastinosG K Karavolias
Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·Jarrod E Church, Wayne C Hodgson
Aug 8, 2002·Toxicon : Official Journal of the International Society on Toxinology·Jarrod E Church, Wayne C Hodgson
Mar 1, 1991·British Heart Journal·A H Henderson
Jan 1, 1995·Mediators of Inflammation·M Clement, M Albertini
Jan 10, 2002·Biochemical and Biophysical Research Communications·Jerome CosteJean Verdetti
Mar 1, 1993·The American Journal of the Medical Sciences·J XieS S Greenberg
Jul 8, 2008·The Journal of Thoracic and Cardiovascular Surgery·Chiyo OotakiKiyotaka Fukamachi
May 8, 2009·Annals of Physical and Rehabilitation Medicine·N TordiJ Regnard
Dec 13, 2005·Journal of Applied Physiology·David R Bell, Kristen Gochenaur
Nov 28, 1991·The New England Journal of Medicine·A Maseri
Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Beihua Zhong, Donna H Wang

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