Abstract
In 21 patients given sevoflurane anesthesia, we simultaneously compared the abilities of Bispectral Index (BIS) and rapidly extracted auditory evoked potentials index (AAI) to display the effect of an increasing cerebral concentration of sevoflurane, with and without noxious stimulation. In addition to BIS/AAI, hemodynamic variables were monitored. After titrating sevoflurane to BIS = 50-55 during 15 min, the end-tidal concentration of sevoflurane (1.46% +/- 0.20%) was doubled followed by a noxious stimulus, laryngoscopy, applied at random time points within the following 15 min. After the end-tidal concentration of sevoflurane was doubled, a substantial reduction in BIS was observed, whereas only a slight reduction in AAI was seen (P < 0.0001). BIS/AAI responses to laryngoscopy were not attenuated with increasing wash-in of sevoflurane. After noxious stimulation, AAI exceeded the highest recommended value, 25, in 3 cases, whereas BIS did not exceed the recommended threshold, 60, in any of the patients. Response times for BIS and AAI were 44.5 +/- 26 and 47 +/- 31 s, respectively. These results suggest that, at a hypnotic level associated with surgical sevoflurane anesthesia, BIS better displays drug-related alterations in the ...Continue Reading
References
Mar 1, 1979·Clinical Pharmacology and Therapeutics·L B SheinerJ Ham
Jun 1, 1970·British Journal of Anaesthesia·D D BriceJ E Utting
Feb 1, 1994·Anesthesiology·A M ZbindenD A Thomson
Feb 18, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W D MiA Matsuki
Mar 20, 1998·British Journal of Anaesthesia·R J GajrajG N Kenny
Sep 22, 1998·Anesthesiology·I J RampilD I Sessler
Oct 20, 1998·Anesthesiology·I J Rampil
May 13, 1999·Anesthesiology·E Olofsen, A Dahan
Oct 28, 1999·British Journal of Anaesthesia·R J GajrajG N Kenny
Nov 30, 1999·Anesthesia and Analgesia·S SchraagM Georgieff
Mar 7, 2000·Lancet·R H SandinC Lennmarken
Jul 21, 2000·Acta Anaesthesiologica Scandinavica·E UrhonenJ Lund
Jan 5, 2002·Journal of Neurosurgical Anesthesiology·Gerhard SchneiderEberhard Kochs
Mar 7, 2002·British Journal of Anaesthesia·A R AbsalomG N Kenny
Apr 10, 2002·Acta Anaesthesiologica Scandinavica·S AlpigerE W Jensen
Apr 20, 2002·Anesthesiology·Cor J Kalkman, John C Drummond
Apr 20, 2002·Anesthesiology·Michel M R F StruysEric P Mortier
Aug 2, 2002·Anesthesiology·Héctor LitvanJuan M Villar Landeira
Oct 16, 2002·British Journal of Anaesthesia·S J GeH T Li
Citations
May 3, 2005·Der Anaesthesist·W WilhelmS Kreuer
Feb 18, 2016·Chinese Medical Journal·Ning YangJian-Dong Gao
May 5, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·E CidonchaA Carrillo
Mar 9, 2007·Anesthesiology Clinics·T Andrew Bowdle
Nov 27, 2008·Anaesthesia·A LamasV Martínez
Feb 14, 2008·Acta Anaesthesiologica Scandinavica·M SandinM Wattwil
Mar 18, 2009·Journal of Veterinary Pharmacology and Therapeutics·S BrásC S Nunes
Nov 3, 2007·Acta Anaesthesiologica Scandinavica·G BaldiniF Carli
Jan 15, 2014·Acta Anaesthesiologica Scandinavica·Y-T LinS-S Hseu
Jan 29, 2013·Research in Veterinary Science·S BrásC S Nunes
Dec 3, 2014·Research in Veterinary Science·S BrásC S Nunes
Apr 6, 2016·IEEE Transactions on Bio-medical Engineering·Yu-Ting Lin, Hau-Tieng Wu
Aug 25, 2007·Anesthesia and Analgesia·Andreas EkmanRolf Sandin
Jan 28, 2006·European Journal of Anaesthesiology·P LambertD Longrois
Aug 23, 2019·Journal of Clinical Monitoring and Computing·Cheng-Hsi ChangYu-Ting Lin
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Anthony G MessinaNathan Leon Pace
Jan 1, 2013·ISRN Pain·Robin Marie ColemanPatricia Bourgault
Mar 24, 2018·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Katarzyna SzostakiewiczDariusz Tomaszewski
Feb 28, 2007·Anesthesiology·Sandeep C ManyamTalmage D Egan