A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study

Radiation Oncology
Shintaro ShibaTakashi Nakano

Abstract

We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma. Data of 477 patients with hepatocellular carcinoma who had undergone carbon ion radiotherapy or transarterial chemoembolization between April 2007 and September 2016 were retrospectively reviewed. Treatment naïve patients with single HCC, who underwent carbon ion radiotherapy or transarterial chemoembolization as a primary treatment were included. Clinical outcomes of the treatments were compared after utilizing propensity score matching. Of 124 patients who received carbon ion radiotherapy and 353 patients who received transarterial chemoembolization, 31 and 23 patients met our inclusion criteria, respectively. After utilizing propensity score matching, 17 matched pairs of patients from each treatment group were analyzed. The median follow-up durations after carbon ion radiotherapy and transarterial chemoembolization were 43 and 32 months, respectively. The 3-year overall survival, local control, and progression-free survival rates in the carbon ion radiotherapy versus transarterial chemoembolization groups were 88% versus 58% (p < 0.05), 80% versus 26% (p < 0.01), and 51% versus 15% (p < 0...Continue Reading

References

Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·T KanaiK Kawachi
Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chung-Mau LoJohn Wong
Jun 29, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hiroshi ImadaHirohiko Tsujii
Jun 29, 2010·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Nobuyuki Kanematsu
Feb 26, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rita GolfieriLuigi Bolondi
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Sep 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Shervin M ShirvaniBenjamin D Smith
Aug 21, 2014·BMC Cancer·Eleonora TerziRita Golfieri
Oct 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yukinori MatsuoMasahiro Hiraoka
Mar 13, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masatoshi KudoYutaka Matsuyama
Jan 7, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Satoshi AbeTakashi Nakano
Sep 22, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Kei ShibuyaUNKNOWN Japan Carbon Ion Radiotherapy Study Group
Oct 28, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kei ShibuyaTakashi Nakano

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Citations

Mar 3, 2020·Frontiers in Oncology·Timothy D MalouffDaniel Michael Trifiletti
Dec 23, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shohei OkazakiTatsuya Ohno
Apr 4, 2021·Cancers·Shintaro ShibaTatsuya Ohno
Jun 28, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung Su Kim, Hong-Gyun Wu

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Software Mentioned

XiO
Statistical Package for the Social Sciences

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