A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
S W YongP H Lee

Abstract

Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) share many similar aspects, and making a clinical diagnosis of one disorder over the other relies heavily on an arbitrary criterion, so-called 1-year rule. This study was designed to search for any difference of metabolic patterns in these two disorders using F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images. We enrolled 16 patients with PD, 13 patients with PDD, and seven patients with DLB. FDG PET was performed, and images were reconstructed by iterative reconstruction using the computed tomography (CT) images, and were normalized to a standard template. Statistical comparison between groups were performed on a voxel-by-voxel basis using t-statistics (two-sample t-test). Compared with the patients with PD, both PDD and DLB patients showed similar patterns of decreased metabolism in bilateral inferior and medial frontal lobes, and right parietal lobe (P(uncorrected) < 0.001). In a direct comparison, DLB patients had significant metabolic decrease (p(uncorrected) < 0.005) in the anterior cingulate compared with those with PDD. These findings support the concept that PDD and DLB have similar underlying neurobiological characteristics, an...Continue Reading

References

Oct 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·H SawadaK Okumiya
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Feb 11, 2000·Neurology·P TiraboschiJ Corey-Bloom
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·M S MegaJ L Cummings
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·H WatanabeG Sobue
Feb 15, 2002·Brain : a Journal of Neurology·A J HardingG M Halliday
Aug 18, 2004·Journal of Geriatric Psychiatry and Neurology·Dag AarslandGlenda Halliday
Oct 7, 2004·Annals of Nuclear Medicine·Kazunari IshiiEtsuro Mori
Aug 17, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·P H LeeK Huh
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB

❮ Previous
Next ❯

Citations

Jan 29, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Chrissa SiokaAthanassios P Kyritsis
Aug 9, 2012·European Journal of Nuclear Medicine and Molecular Imaging·David Garcia-GarciaMaria C Rodriguez-Oroz
Dec 23, 2011·Parkinsonism & Related Disorders·Nicola Pavese
Nov 19, 2009·Brain : a Journal of Neurology·Yasuhiro NagahamaMinoru Matsuda
May 4, 2012·Cold Spring Harbor Perspectives in Medicine·Martin NiethammerDavid Eidelberg
Nov 12, 2014·Nature Reviews. Neurology·Marios Politis
Jul 7, 2012·Imaging in Medicine·Myria PetrouNicolaas I Bohnen
Aug 28, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Swetha VijayaraghavanTaher Darreh-Shori
Jun 9, 2015·PET Clinics·Michael SchöllHenry Engler
Jun 22, 2014·Brain : a Journal of Neurology·Rafael González-RedondoMaría C Rodríguez-Oroz
May 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Richard K J BrownKirk A Frey
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul EdisonDavid J Brooks
Sep 1, 2013·Current Translational Geriatrics and Experimental Gerontology Reports·Stella Karantzoulis, James E Galvin
Mar 6, 2015·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Ana M Catafau, Santiago Bullich
Apr 19, 2015·Brain : a Journal of Neurology·James GratwickeThomas Foltynie
Apr 10, 2015·BMC Medicine·Gerwyn MorrisMichael Maes
May 27, 2015·Current Neurology and Neuroscience Reports·María C Rodriguez-OrozHaritz Jimenez-Urbieta
Nov 12, 2014·Frontiers in Neurology·Fabiola De MarchiCristoforo Comi
Jun 26, 2009·Parkinsonism & Related Disorders·Carlo RossiRoberto Ceravolo
Aug 28, 2012·Revue neurologique·S ThoboisE Broussolle
Sep 28, 2010·Parkinsonism & Related Disorders·Pekka JokinenJuha O Rinne
Mar 4, 2017·Nature Reviews. Neurology·Dag AarslandClive Ballard
Dec 19, 2016·Seminars in Nuclear Medicine·Atul MallikSatoshi Minoshima
Mar 24, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tao JinSeong-Gi Kim
Sep 30, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Julie A Fields
Feb 15, 2019·Journal of Neural Transmission·Heather WilsonMarios Politis
Jun 5, 2010·Brain Pathology·Lisa C Silbert, Jeffrey Kaye
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Laura K TeuneKlaus L Leenders
Mar 8, 2018·BMC Medicine·Kurt A Jellinger, Amos D Korczyn
Nov 13, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Ji E LeePhil Hyu Lee
May 5, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Mélanie VendetteJacques Montplaisir
Jul 2, 2011·Annals of the New York Academy of Sciences·Valentina BertiLisa Mosconi
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Brit MollenhauerDavid Brooks
Jun 3, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Inga LiepeltDaniela Berg
Apr 29, 2015·Nuclear Medicine Communications·Ismet Sarikaya
May 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Manuel Delgado-AlvaradoMaría C Rodriguez-Oroz
Apr 1, 2017·Translational Neurodegeneration·Usman SaeedMario Masellis
Dec 2, 2017·Human Brain Mapping·Julia SchumacherJohn-Paul Taylor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.