A comparison of cholinesterase activity after intravenous, oral or dermal administration of methyl parathion

Journal of Biomedical Science
R E KramerRodney C Baker

Abstract

Time-dependent changes in blood cholinesterase activity caused by single intravenous, oral or dermal administration of methyl parathion to adult female rats were defined. Intravenous and oral administration of 2.5 mg/kg methyl parathion resulted in rapid (<60 min) decreases in cholinesterase activity which recovered fully in vivo within 30-48 h. In contrast, spontaneous reactivation of cholinesterase in vitro was complete within 6 h at 37 degrees C. Dermal administration of methyl parathion caused dose-dependent inhibition of cholinesterase activity which developed slowly (> or =6 h) and was prolonged (> or =48 h). Time- and route-dependent effects of methyl parathion on cholinesterase activity in brain and other tissues generally paralleled its effects on activity in blood. In conclusion, pharmacodynamics of methyl parathion differ substantially with route of exposure. Recovery of cholinesterase in vivo after intravenous or oral exposure may partially reflect spontaneous reactivation and suggests a rapid clearance of methyl parathion or its active metabolite methyl paraoxon. The more gradual and prolonged inhibition of cholinesterase caused by dermal administration is consistent with disposition of methyl parathion at a site f...Continue Reading

References

Jan 1, 1975·Archives of Environmental Contamination and Toxicology·H R WolfeW F Durham
Nov 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M P Carver, J E Riviere
Mar 26, 1987·The New England Journal of Medicine·N Senanayake, L Karalliedde
Jan 1, 1988·Archives of Environmental Health·E P SavageP J Burcar
Feb 1, 1987·Archives of Toxicology·E De SchryverJ Willems
Jul 1, 1974·Bulletin of Environmental Contamination and Toxicology·G M Benke, S D Murphy
Apr 1, 1972·Radiology·F H Bledsoe, E Q Seymour
Jan 26, 1966·Annals of the New York Academy of Sciences·E B Wilson
May 1, 1969·Toxicology and Applied Pharmacology·T B Gaines
Jan 1, 1983·Advances in Clinical Chemistry·E J van Kampen, W G Zijlstra
Apr 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W D Dettbarn
Jan 1, 1980·Pharmacology & Therapeutics·A P Kulkarni, E Hodgson
Mar 1, 1982·Journal of Pharmacobio-dynamics·T Matsubara, I Horikoshi
Mar 1, 1982·Journal of Toxicology and Environmental Health·C S Skinner, W W Kilgore
Feb 1, 1980·Archives of Toxicology·R A BraeckmanJ L Willems
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J E Chambers, R L Carr
Aug 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A C NostrandtS Padilla
Aug 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R C WesterH I Maibach
Dec 24, 1997·Bulletin of Environmental Contamination and Toxicology·R García-RepettoM Repetto
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D F BussolinoB L Caputto
Sep 1, 1956·British Journal of Pharmacology and Chemotherapy·F HOBBIGER
Jan 1, 1960·Toxicology and Applied Pharmacology·T B GAINES
Aug 1, 1959·Biochimica Et Biophysica Acta·F BERENDSF A DEIERKAUF

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Citations

Jul 1, 2011·Environmental Science and Pollution Research International·Agustín BassoJuan Carlos Sanchez-Hernandez
May 1, 2005·Environmental Toxicology and Pharmacology·Axel MuttrayGeorg Hill
Sep 14, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Geoffrey K IsbisterMichael Eddleston
Jul 16, 2016·Chemico-biological Interactions·Shlomit DachirTamar Kadar
Jul 7, 2011·Bulletin of Entomological Research·D B RiversR Brogan
Jul 5, 2006·International Journal of Environmental Research and Public Health·Falicia L Edwards, Paul B Tchounwou

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