PMID: 329975Aug 1, 1977Paper

A comparison of cyclophosphamide, adriamycin, 5-fluorouracil (CAF) and cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, prednisone (CMFVP) in patients with metastatic breast cancer: a Southeastern Cancer Study Group project

R V SmalleyS Krauss


In an ongoing prospective randomized study, 113 evaluable patients have received either a three-drug combination that included cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) or a five-drug combination including cyclophosphamide, methotrexate, 5-fluorouracil, vincristine and prednisone (CMFVP) given intermittently 1 week out of 4. Responses (64%), median duration of response (32 weeks), and median duration of disease control (32 weeks) achieved with CAF were superior to those achieved with CMFVP (37%, 22 weeks, 17 weeks, respectively). Morbidity secondary to CAF was significant, with nausea and vomiting, malaise, total alopecia, and granulocytopenia being the main features.


Jan 1, 1994·Journal of Surgical Oncology·S SchneebaumJ P Minton
Jan 1, 1985·Breast Cancer Research and Treatment·D C TormeyP P Carbone
Apr 30, 1995·Breast Cancer : the Journal of the Japanese Breast Cancer Society·T WadaM Yasutomi
Dec 1, 1985·Journal of Steroid Biochemistry·M R SertoliR Rosso
Dec 1, 1985·Journal of Steroid Biochemistry·F CavalliK W Brunner
Dec 1, 1983·International Journal of Radiation Oncology, Biology, Physics·R V SmalleyJ Wittliff
May 19, 2000·Breast Cancer Research and Treatment·M YoshimotoF Kasumi
Jan 10, 1980·The New England Journal of Medicine·I C Henderson, G P Canellos
Jun 3, 2005·The New England Journal of Medicine·Miguel MartinBreast Cancer International Research Group 001 Investigators
Dec 11, 2008·Journal of the National Cancer Institute·Davide MauriJohn P A Ioannidis
Nov 5, 2005·Acta Haematologica·Axel R Zander, Nicolaus Kroger
Nov 1, 1986·The Journal of Clinical Investigation·N A Berger
Jan 1, 1987·Acta Oncologica·S Gundersen, S Kvinnsland
Jan 1, 1979·Acta Radiologica: Oncology, Radiation, Physics, Biology·W MattssonC E Lindholm
Jan 1, 1992·Acta Oncologica·C KambyH T Mouridsen
Mar 1, 1985·Cancer Treatment Reviews·W P BradeM Varini
Dec 1, 1985·Cancer Treatment Reviews·R E Coleman, R D Rubens
Jul 1, 1991·Current Problems in Cancer·M A BookmanR M Scher
Apr 1, 1981·The American Journal of Medicine·R B WeissV T DeVita
Mar 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S KaasaL Carruthers
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FalksonH C Falkson
Jan 1, 1988·Seminars in Surgical Oncology·J H Ward, H J Eyre
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Clavel, G Catimel
Jul 1, 1980·Clinical Radiology·B HancockP M Wilkinson
Jun 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George W SledgeAntonio C Wolff
Dec 19, 2002·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Thomas MorrowWilliam Carter
Dec 18, 2001·Cancer·B K LinkOncology Practice Pattern Study Working Group
Oct 21, 2004·The Cochrane Database of Systematic Reviews·S LordJ Simes
Apr 18, 2001·The Oncologist·F J EstevaG N Hortobagyi
Aug 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lin DaiLi-Qun Guo

Related Concepts

Antineoplastic Agents
Malignant Bone Neoplasm
Mammary Neoplasms, Human
Clinical Trials
Cyclophosphamide, (S)-Isomer
5-FU medac
Methotrexate, (DL)-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.