A comparison of dialysers with low-flux membranes: significant differences in spite of many similarities

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
R A WardH Klinkmann

Abstract

The solute removal characteristics and haemocompatibility of low-flux dialysers containing Cuprophan, cellulose acetate, polymethylmethacrylate (PMMA), and polycarbonate-polyether (Gambrane) membranes were compared in a multicentre cross-over clinical trial. While all four dialysers provided comparable removal of urea and creatinine, the dialyser containing PMMA membrane showed a reduced ability to remove phosphate compared to that containing Cuprophan membrane. Significant beta 2-microglobulin removal was obtained with the dialyser containing Gambrane membrane, whereas the other three dialysers had no impact on plasma beta 2-microglobulin concentrations. The ability to activate complement, measured as changes in the plasma concentrations of C3a des Arg and the terminal complement complex, and to produce leukopenia was greater for the dialyser containing Cuprophan membrane than for the other three. The ability to activate complement and cause leukopenia was not consistent among the remaining three dialysers and the degree of leukopenia could not be predicted from the level of complement activation. Neutrophil degranulation, as indicated by the release of elastase-alpha 1-proteinase inhibitor, occurred to a greater extent with t...Continue Reading

Citations

Jul 9, 2002·Seminars in Dialysis·William R Clark, Dayong Gao
Jul 22, 2005·The Cochrane Database of Systematic Reviews·A M MacleodS Wallace
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli
Jun 22, 2001·Renal Failure·V GasparovićD Ivanović
Nov 30, 2000·Journal of the American Society of Nephrology : JASN·Richard A WardWalter Samtleben
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·B MemoliB Guida

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