A comparison of different nanostructured biomaterials in subcutaneous tissue

Journal of Materials Science. Materials in Medicine
Julia C VogtMartin Stieve

Abstract

The nanostructured surface of a material can improve its interaction with cells and its acceptance as an implant. We compared two novel biomaterials with different nanostructures: Bioverit II with a coating of nanoporous silica and chitosan-hydroxyapatite composite materials. Pure Bioverit II served as a control. Platelets of these materials were implanted for 28, 85 and 300 days in the subcutaneous tissue in the neck of 38 rabbits. After excising the specimens they were fixed, embedded in epoxy resin and analyzed histologically. All coated Bioverit II implants showed a thin capsule of connective tissue. After 300 days, these capsules tended to be thicker than in pure Bioverit II. No signs of inflammation were observed and the materials appeared unaltered by visual inspection. In case of chitosan-hydroxyapatite composites, massive capsules consisting of dense connective tissue were found, and the material showed signs of biodegradation in form of fissures and cavities. In conclusion, the nanoporous coating showed no obvious positive effect with regard to capsule formation; the chitosan-hydroxyapatite implants provoked a stronger interaction between cells and material. However, most Bioverit II implants showed no alterations opt...Continue Reading

References

Apr 1, 1990·Journal of Biomedical Materials Research·C A van BlitterswijkK de Groot
Mar 1, 1990·Journal of Biomedical Materials Research·J A JansenK de Groot
Mar 1, 1986·The Annals of Otology, Rhinology & Laryngology. Supplement·J J Grote
Feb 18, 1999·Biomaterials·H Onishi, Y Machida
Jul 8, 1999·Biomaterials·T J WebsterR Bizios
Jun 21, 2001·ANZ Journal of Surgery·W R MooreG I Bain
Jan 5, 2002·Journal of Biomedical Materials Research·Pamela J VandeVordPaul H Wooley
Dec 25, 2002·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Philipp DostKlaus Jahnke
Aug 12, 2003·Journal of Nanoscience and Nanotechnology·Shane A CatledgeRamakrishna Venugopalan
May 4, 2004·Biomaterials·Thomas J Webster, Jeremiah U Ejiofor
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·A L DoadrioM Vallet-Regí
May 19, 2004·Biomaterials·Seok Bong KimJung-Woog Shin
Aug 31, 2004·Journal of Materials Science. Materials in Medicine·B G CousinsM J Garvey
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·A SabokbarN A Athanasou
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·H YuanK De Groot
Jul 22, 2005·Journal of Biomedical Materials Research. Part a·Thomas J Webster, Tyler A Smith
Jul 27, 2005·Journal of Biomedical Materials Research. Part a·Lijun KongXiufang Zhang
Jul 13, 2006·Chemistry : a European Journal·María Vallet-Regí
Aug 31, 2007·Acta Oto-laryngologica·Christina TurckMartin Stieve

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Citations

Nov 20, 2013·Annals of Biomedical Engineering·Eric M SussmanBuddy D Ratner
Nov 19, 2011·Journal of Materials Science. Materials in Medicine·Minyu LiWanshun Liu
Oct 12, 2012·Journal of Materials Science. Materials in Medicine·Daniela HesseNils Kristian Prenzler
Jul 19, 2011·Biomacromolecules·Victor T TchemtchouaAlain Colige
Aug 13, 2015·Journal of Materials Science. Materials in Medicine·Satoshi HayakawaAkiyoshi Osaka
Jan 13, 2015·Journal of Materials Science. Materials in Medicine·Franziska DudaNils Kristian Prenzler
Jul 22, 2014·Annals of Plastic Surgery·Paul DiEgidioRichard L Goodwin
Apr 20, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Daniela HesseNils Kristian Prenzler
Mar 26, 2013·Chemical Society Reviews·Nina EhlertPeter Behrens

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