A comparison of direct aspiration versus stent retriever as a first approach ('COMPASS'): protocol

Journal of Neurointerventional Surgery
Aquilla S TurkJ Mocco

Abstract

Acute ischemic stroke is a potentially devastating condition and leading cause of morbidity and mortality, affecting an estimated 800 000 people per year in the USA. The natural history of untreated or unrevascularized large vessel occlusions in acute stroke patients results in mortality rates approaching 30%, with only 25% achieving good neurologic outcomes at 90 days. Recently, data have demonstrated that early endovascular recanalization of large vessel occlusions results in better outcomes than medical therapy alone. However, the majority of patients in these studies were treated with a stent retriever based approach. The purpose of COMPASS is to evaluate whether patients treated with a direct aspiration first pass (ADAPT) approach have non-inferior functional outcomes to those treated with a stent retriever as the firstline (SRFL) approach. All patients who meet the inclusion and exclusion criteria and consent to participate will be enrolled at participating centers. Treatment will be randomly assigned by a central web based system in a 1:1 manner to treatment with either ADAPT or SRFL thrombectomy. Statistical methodology is prespecified with details available in the statistical analysis plan. The trial recently completed...Continue Reading

Associated Clinical Trials

References

Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·P W DuncanL J Laster
Dec 6, 2005·Cerebrovascular Diseases·Randall T Higashida
Apr 30, 2013·Journal of Neurointerventional Surgery·Aquilla S TurkImran Chaudry
Feb 27, 2014·Journal of Neurointerventional Surgery·Aquilla S TurkImran Chaudry
Dec 18, 2014·The New England Journal of Medicine·Olvert A BerkhemerUNKNOWN MR CLEAN Investigators
Apr 18, 2015·The New England Journal of Medicine·Jeffrey L SaverUNKNOWN SWIFT PRIME Investigators
Aug 4, 2016·Stroke; a Journal of Cerebral Circulation·J MoccoUNKNOWN THERAPY Trial Investigators*

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Citations

Oct 7, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Pierre De MariniBenjamin Gory
Apr 19, 2018·Journal of Neurointerventional Surgery·Ali AlawiehAlejandro M Spiotta
Feb 1, 2019·Rinshō shinkeigaku = Clinical neurology·Mikito Hayakawa
Feb 9, 2019·Journal of Stroke·Tommy AnderssonLeonard L L Yeo
Oct 10, 2018·Journal of Neurointerventional Surgery·Alejandro M SpiottaJoshua A Hirsch
Feb 6, 2019·Journal of Neurointerventional Surgery·Rose A ArslanianJu-Yu Chueh
Sep 30, 2019·Journal of Neurointerventional Surgery·Dong-Hun KangYong-Sun Kim
May 16, 2020·Stroke and Vascular Neurology·Ahmad SweidPascal Jabbour
Jul 24, 2018·Current Neurology and Neuroscience Reports·Aravind Ganesh, Mayank Goyal
Jul 19, 2020·Journal of Neurointerventional Surgery·Maxim MokinJ Mocco
Dec 12, 2019·Current Treatment Options in Cardiovascular Medicine·Julian MaingardThabele M Leslie-Mazwi
Oct 12, 2019·Nature Reviews. Disease Primers·Bruce C V CampbellGeoffrey A Donnan
Oct 8, 2020·Journal of Neurointerventional Surgery·Jan VargasAquilla Turk
Nov 11, 2020·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·B FriedrichC Maegerlein

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