A comparison of direct reconstruction algorithms in proton computed tomography

Physics in Medicine and Biology
Feriel KhellafS Rit

Abstract

Several direct algorithms have been proposed to take into account the non-linear path of protons in the reconstruction of a proton CT (pCT) image. This paper presents a comparison between five of them, in terms of spatial resolution and relative stopping power (RSP) accuracy. Our comparison includes (1) a distance-driven algorithm extending the filtered backprojection to non-linear trajectories (DD), (2) an algorithm reconstructing a pCT image from optimized projections (ML), (3) a backproject-then-filter approach using a 2D cone filter (BTF), (4) a differentiated backprojection algorithm based on the inversion of the Hilbert transform (DBP), and (5) an algorithm using a 2D directional ramp filter (DR). We have simulated a single tracking pCT set-up using Geant4 through GATE, with a proton source and two position, direction and energy detectors upstream and downstream from the object. Tracker uncertainties were added on the position and direction measurements. A Catphan 528 phantom and a spiral phantom were simulated to measure the spatial resolution and a Gammex 467 phantom was used for the RSP accuracy. Each proton's trajectory was estimated using a most likely path (MLP) formalism. The spatial resolution was evaluated using ...Continue Reading

References

Aug 3, 2004·Physics in Medicine and Biology·D C Williams
Oct 9, 2004·Physics in Medicine and Biology·Frédéric NooJed D Pack
May 11, 2012·Physics in Medicine and Biology·Harald Paganetti
Mar 8, 2013·Medical Physics·Simon RitJean Michel Létang
Mar 7, 2014·Medical Physics·David C HansenThomas Sangild Sørensen
Nov 6, 2014·Medical Physics·David C HansenJoao Seco
Nov 27, 2014·Physics in Medicine and Biology·G PoludniowskiP M Evans
Jun 11, 2015·Physics in Medicine and Biology·Charles-Antoine Collins FeketeJoao Seco
Jul 23, 2016·Physics in Medicine and Biology·David C HansenSimon Rit
Nov 5, 2016·Physics in Medicine and Biology·Charles-Antoine Collins-FeketeJoao Seco
Dec 3, 2016·Medical Physics·Tia E PlautzA Zatserklyaniy
Sep 9, 2017·Reports on Progress in Physics·Robert P Johnson
Aug 31, 2019·Physics in Medicine and Biology·D SarrutJ M Létang
Mar 7, 2020·Physics in Medicine and Biology·Feriel KhellafSimon Rit

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Citations

Mar 7, 2020·Physics in Medicine and Biology·Feriel KhellafSimon Rit
Mar 19, 2021·Physics in Medicine and Biology·Thomas AckernleyMarco Cristoforetti
Apr 14, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Stefanie KaserFelix Ulrich-Pur
Feb 24, 2021·Physics in Medicine and Biology·Brent van der HeydenEdmond Sterpin

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