A comparison of disease severity and survival rates after liver transplantation in the United Kingdom, Canada, and the United States

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
David A StellDouglas Thorburn

Abstract

The severity of preoperative liver disease influences the outcome of liver transplantation, is commonly used to determine priority on liver transplant waiting lists, and may differ between countries with different rates of liver disease and organ allocation systems. We compared the relative severity of liver disease in transplant recipients with chronic liver disease in the United States, Canada, and the United Kingdom and its relation to outcome. Data were obtained from national databases on patients who received transplants in the year 2000. The data included age, gender, diagnosis, the status at the time of transplantation, and indices of chronic liver disease [serum bilirubin and international normalized ratio (INR), and serum creatinine] from which a comparative score [model for end-stage liver disease (MELD) score] was calculated. The data revealed marked differences between the three countries. No patient in the United Kingdom was in intensive care before transplantation compared with 19.3% of recipients in the United States and 7.5% in Canada. The median model MELD score of recipients in the United Kingdom was 10.9 compared with 16.1 in the United States and 17 in Canada. The median MELD score of transplant recipients i...Continue Reading

References

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Citations

May 10, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John G LunzAnthony J Demetris
Feb 15, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marwan Ghabril
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M RavaioliA D Pinna
Jan 5, 2005·Journal of Hepatology·Richard B Freeman
Mar 15, 2005·Clinics in Liver Disease·Rowen K Zetterman
Nov 5, 2008·Medical Care Research and Review : MCRR·Christian S van der HilstElisabeth M Tenvergert
Mar 14, 2018·Occupational Medicine·E R Waclawski, P Noone
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James Neuberger
Feb 11, 2014·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Eleazar ChaibLuiz Augusto Carneiro D'Albuquerque

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