A comparison of distinct modes of tumor cell death in Hodgkin's disease using morphology and in situ DNA fragmentation

Ultrastructural Pathology
Daniel BenharrochJacob Gopas

Abstract

The study examined the morphology and frequency of cell death occurring spontaneously in lymph nodes from patients with Hodgkin's disease. In addition to necrosis, which was infrequent and usually in patches, we document two cell types showing features of individual cell death: mummy cells end apoptotic cells. Mummy cells present no evidence of DNA fragmentation, but show electron microscopic features of "dark cells." Apoptotic Hodgkin-Reed-Sternberg cells are found frequently and are easier to demonstrate by in situ and labeling of fragmented DNA than by light microscopy only. In many cases phagocytosis of apoptotic cells is also documented. The significance of these findings to the limited number of Hodgkin-Reed-Sternberg cells in most cases of Hodgkin's disease is discussed.

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Citations

Apr 30, 1999·Leukemia & Lymphoma·D BenharrochJ Gopas
Oct 30, 2008·Virchows Archiv : an International Journal of Pathology·Daniel BenharrochMartin Sacks
Aug 26, 1998·The Journal of Pathology·D BenharrochJ Gopas
May 19, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Daniel BenharrochJacob Gopas
Jan 26, 2006·The American Journal of Surgical Pathology·José VassalloGeorges Delsol
Nov 7, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Alexandar Tzankov, Stephan Dirnhofer

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