A Comparison of Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Fine-Needle Biopsy in the Diagnosis of Solid Pancreatic Lesions

Canadian Journal of Gastroenterology & Hepatology
Lachlan R AyresJennifer J Telford

Abstract

Endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) is the method of choice for sampling pancreatic lesions. This study compares the diagnostic accuracy and safety of FNB using a novel core needle to FNA in solid pancreatic lesions. A retrospective review of patients in whom EUS FNA or FNB was performed for solid pancreatic lesions was conducted. Diagnostic performance was calculated based upon a dual classification system: classification 1, only malignant pathology considered a true positive, versus classification 2, atypical, suspicious, and malignant pathology considered a true positive. 43 patients underwent FNB compared with 51 FNA. Using classification 1, sensitivity was 74.0% versus 80.0%, specificity 100% versus 100%, and diagnostic accuracy 77.0% versus 80.0% for FNB versus FNA, respectively (all p > 0.05). Using classification 2, sensitivity was 97% versus 94.0%, specificity 100% versus 100%, and diagnostic accuracy 98.0% versus 94.0% for FNB versus FNA, respectively (all p > 0.05). FNB required significantly fewer needle passes (median = 2) compared to FNA (median = 3; p < 0.001). Adverse events occurred in two (4.5%) FNB patients compared with none in the FNA group (p > 0.05). FNA and FNB have comparable...Continue Reading

References

Jun 27, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Michael J Levy
Jul 29, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·P Thomas CherianBrinder S Mahon
May 6, 2011·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shigetaka YoshinagaYutaka Saito
May 20, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Carlo FabbriNicola D'Imperio
Jan 18, 2012·Gastrointestinal Endoscopy·Michael Jonathan HewittKevin J Monahan
Dec 17, 2014·Journal of Gastroenterology·Keiji HanadaShuji Yonehara
Aug 19, 2015·United European Gastroenterology Journal·Abdullah AlatawiFrédéric Prat
Feb 18, 2016·Endoscopic Ultrasound·Manoop S BhutaniKenji Yamao

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Citations

Dec 10, 2019·Clinical Endoscopy·Jae Keun Park, Kwang Hyuck Lee
Oct 1, 2020·World Journal of Gastrointestinal Endoscopy·Chi Wing ChowSuresh Vasan Venkatachalapathy
May 30, 2020·Diagnostics·Robert DorrellRishi Pawa

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Methods Mentioned

BETA
biopsy

Software Mentioned

SAS
R

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