A comparison of endothelial and penetrating keratoplasty outcomes following failed penetrating keratoplasty: a registry study

The British Journal of Ophthalmology
Miriam C Keanefor Contributors to the Australian Corneal Graft Registry

Abstract

To compare graft survival and visual outcomes for endothelial keratoplasty (EK) after a first penetrating keratoplasty (PK), with outcomes of repeat PK after a first PK. 400 eyes with a second graft (65 EKs, 335 PKs) performed after failure of a primary PK were identified through the Australian Corneal Graft Registry, a national prospectively followed cohort. Grafts were performed after January 2008 (follow-up of the second graft extending to 6.75 years maximum). Kaplan-Meier graft survival plots were constructed and Cox proportional hazards regression was used to identify independent risk factors for graft failure. Best-corrected Snellen visual acuity (BCVA) at last follow-up was compared with pregraft acuity. Poor Kaplan-Meier graft survival was observed for PK-EK compared with PK-PK (log-rank=29.66, p<0.001). Variables retained in multivariate analysis as significantly influencing survival of the second graft included graft type (PK-EK or PK-PK, p<0.001), length of survival of the previous PK (global p=0.011), graft era (global p=0.018), occurrence of rejection in the second graft (p=0.005) and a history of raised intraocular pressure at any time (p=0.048), but not indication for the first graft. BCVA improved in the majorit...Continue Reading

Citations

Nov 26, 2019·Transplantation·W John ArmitageBertrand Vabres
Feb 6, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sonja HeinzelmannPhilip Maier
Jun 23, 2018·JAMA Ophthalmology·Jonathan AboshihaDaniel F P Larkin
Mar 17, 2017·Journal of Ophthalmic & Vision Research·Tulio B AbudReza Dana
Jun 24, 2020·American Journal of Ophthalmology·Sidra ZafarDivya Srikumaran

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