PMID: 2406328Feb 1, 1990

A comparison of enprofylline and theophylline in the maintenance therapy of chronic reversible obstructive airway disease

The Journal of Allergy and Clinical Immunology
K R ChapmanS Peters


To compare the efficacy and side effects of two xanthine derivatives in the maintenance therapy of reversible obstructive airway disease, 242 patients were assigned in randomized, double-blind fashion to receive either oral enprofylline or theophylline for 5 weeks in addition to their usual maintenance regimens. After a week of placebo xanthine therapy, enprofylline-treated patients received 150 mg of this drug twice daily (b.i.d.) for 3 days, 300 mg b.i.d. for 2 weeks, and 450 mg b.i.d. for 2 weeks. Theophylline was administered in identical doses, except that the final dosage increase was not made if plasma theophylline was 12 mg/ml or higher. At 300 mg b.i.d., both drugs significantly increased morning peak expiratory flow rate (PEFR), the mean increase above baseline being significantly higher for theophylline-treated patients (29.9 +/- 37.2 L/min) than for enprofylline-treated patients (17.4 +/- 36.9 L/min) (p = 0.023). At 450 mg b.i.d., improvement in morning PEFR was not significantly different between theophylline-treated (31.5 +/- 44.4 L/min) and enprofylline-treated groups (23.5 +/- 48.4 L/min). Evening PEFR, FEV1, and asthma symptom scores also improved significantly, demonstrating no significant difference between g...Continue Reading


Mar 1, 1989·The American Review of Respiratory Disease·K R ChapmanN Ringdal
Sep 20, 1973·The New England Journal of Medicine·P A Mitenko, R I Ogilvie
Jan 1, 1984·European Journal of Clinical Pharmacology·K E AnderssonC Persson


May 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U Serafini
Jan 1, 1991·Upsala Journal of Medical Sciences·C JansonC Persson
Jan 10, 2003·The Cochrane Database of Systematic Reviews·F S RamS Cendon

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