A comparison of false positives in retinal nerve fiber layer, optic nerve head and macular ganglion cell-inner plexiform layer from two spectral-domain optical coherence tomography devices

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Marina Leal-FonsecaF J Muñoz-Negrete

Abstract

The incidence of false positive (FP) results of optic coherence tomography (OCT) retinal nerve fiber layer (RNFL) color code in healthy subjects can be very high with Cirrus OCT. Recent evidence has shown that OCT parameters derived from macular ganglion cell-inner plexiform layer (GCIPL) have excellent ability to discriminate between normal eyes and eyes with early glaucoma. This was a prospective, cross-sectional study. One hundred eyes from 50 healthy volunteers underwent circumpapillary scanning by Cirrus and Spectralis OCT and macular scanning using Cirrus OCT. FP rates for each of the OCT parameters, using predefined criteria for an abnormal test were calculated. Comparative analysis was performed using the McNemar test. A generalized estimating equations model (GEE) was used to compare demographic and clinical factors between the eyes with normal findings and eyes with abnormal results. The overall RNFL color-code FP rate was significantly higher for Cirrus (39 %) than for Spectralis (18 %) (P = 0.000). The Spectralis RNFL FP rate showed no significant difference when compared to the FP rate by Cirrus GCIPL (13 %) and ONH (11 %) analysis. Axial length, mean spherical equivalent, presence of peripapillary atrophy, and til...Continue Reading

References

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Aug 24, 2012·The British Journal of Ophthalmology·Jacek KotowskiJoel S Schuman
Jan 30, 2013·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Jean-Claude MwanzaDonald L Budenz

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Citations

Apr 11, 2015·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Gema RebolledaFrancisco J Muñoz-Negrete
Jun 27, 2015·Ophthalmology·Ko Eun KimKi Ho Park
Mar 25, 2015·Archivos de la Sociedad Española de Oftalmología·G Rebolleda, F J Muñoz-Negrete
Dec 17, 2014·American Journal of Ophthalmology·Huseyin SimavliTeresa C Chen
Dec 7, 2018·Translational Vision Science & Technology·Javier Moreno-MontañésAlfonso Antón
Jan 13, 2017·Journal of Glaucoma·Huseyin SimavliTeresa C Chen
Mar 18, 2021·Clinical Ophthalmology·Pedro Manuel BaptistaMaria João Menéres
Dec 19, 2020·Journal of Glaucoma·Donald C HoodCarlos G De Moraes

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