A Comparison of GATA3, TTF1, CD10, and Calretinin in Identifying Mesonephric and Mesonephric-like Carcinomas of the Gynecologic Tract

The American Journal of Surgical Pathology
Jennifer PorsLynn Hoang

Abstract

Mesonephric carcinomas of the gynecologic tract are neoplasms that are often under-recognized due to their varied morphologic appearances. Recently, GATA3 and TTF1 have been reported to be useful immunohistochemical markers for distinguishing mesonephric carcinomas from its morphologic mimics. Herein, we compared the performance of GATA3 and TTF1 to the traditional markers used for mesonephric carcinomas, CD10 and calretinin. We studied 694 cases: 8 mesonephric carcinomas (7 cervical [includes 3 mesonephric carcinosarcomas], 1 vaginal), 5 mesonephric-like carcinomas (4 uterine corpus, 1 ovarian), 585 endometrial adenocarcinomas, and 96 cervical adenocarcinomas. Mesonephric-like carcinomas were defined as tumors exhibiting the classic morphologic features of mesonephric carcinoma, but occurring outside of the cervix and without convincing mesonephric remnants. GATA3 had the highest sensitivity and specificity (91% and 94%) compared with TTF1 (45% and 99%), CD10 (73% and 83%), and calretinin (36% and 89%). GATA3, however, also stained a substantial number of uterine carcinosarcomas (23/113, 20%). TTF1 was positive in 5/5 (100%) mesonephric-like carcinomas and only 1/8 (13%) mesonephric carcinomas. In 4/6 (67%) TTF1 positive cases...Continue Reading

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Citations

Nov 15, 2019·The American Journal of Surgical Pathology·Elizabeth D EuscherAnais Malpica
Nov 13, 2019·The American Journal of Surgical Pathology·Jennifer PorsLynn N Hoang
Jul 31, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jennifer PorsLynn Hoang
Mar 25, 2020·Advances in Anatomic Pathology·Andrew M Bellizzi
Oct 9, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer A BennettEsther Oliva
Jan 28, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Yun LiangXiaofei Zhang
Sep 23, 2020·The American Journal of Surgical Pathology·Daniel GrosserJonathan I Epstein
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Dec 8, 2020·The American Journal of Surgical Pathology·Gladell P PanerMahul B Amin
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Mar 28, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Edaise M da SilvaKay J Park
Oct 23, 2020·Archives of Pathology & Laboratory Medicine·Laurie M GriesingerStephanie L Skala
Jul 6, 2021·World Journal of Clinical Cases·Chuan XieCe Bian
Sep 29, 2021·The Journal of Obstetrics and Gynaecology Research·Mari UjitaIkuo Konishi
Jun 30, 2021·The American Journal of Surgical Pathology·Ellen DeoletW Glenn McCluggage

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Methods Mentioned

BETA
hysterectomy
biopsies
biopsy

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