A comparison of goserelin and danazol as endometrial thinning agents prior to endometrial laser ablation

British Journal of Obstetrics and Gynaecology
R GarryM Stuart

Abstract

To compare the effectiveness of goserelin and danazol prior to endometrial laser ablation and assess different dosage regimens. A prospective open randomised trial. Specialist unit in minimal access gynaecological surgery in a district general hospital. One hundred and sixty premenopausal women with dysfunctional uterine bleeding. Randomisation into four groups receiving either one or two injections of goserelin acetate (3.6 mg subcutaneously) or 28 or 56 days of danazol (four 200 mg tablets daily), followed by endometrial laser ablation. Endometrial thickness pretreatment and, immediately prior to endometrial laser ablation, assessed by vaginal ultrasound and full thickness endometrial biopsy; appearance of the endometrium at surgery; duration of the operation; the amount of fluid absorbed during surgery; and the clinical outcome at 24 weeks after surgery. The two drugs were equally effective in thinning the endometrium. Compared with danazol, goserelin was better tolerated and resulted in a more satisfactory endometrial appearance at hysteroscopy, a greater reduction in cavity length (0.5 cm compared with 0.3 cm, P = 0.002), a shorter operation (16.4 min compared with 21.6 min, P < 0.001), less fluid absorption (0 ml compared...Continue Reading

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