A comparison of human and murine monoclonal IgGs specific for the P1.7 PorA protein of Neisseria meningitidis

Molecular Immunology
A A DelvigM Achtman

Abstract

Monoclonal human IgG SS269 reacts with Neisseria meningitidis expressing the P1.7 PorA protein and with linear peptides containing NGGAS, which accounts for the P1.7 specificity. Murine monoclonal antibody to P1.7 reacts with peptides containing the overlapping epitope, ASGQ. The human and murine antibodies have similar affinities. The low avidity human antibody is very inefficient at stimulating complement-mediated bactericidal killing while the high avidity murine antibody efficiently kills bacteria. However, efficient opsonophagocytosis was mediated even at low concentrations of the human antibody and in the absence of complement, suggesting that low avidity antibodies might be protective against disease.

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M K GornyS Zolla-Pazner
Jul 1, 1985·Reviews of Infectious Diseases·C E FraschJ T Poolman
Jun 26, 1987·Journal of Immunological Methods·J D BeattyW G Vlahos
Sep 24, 1987·Journal of Immunological Methods·H M GeysenP G Schoofs
May 1, 1986·Journal of Immunological Methods·W L CarrollR Levy
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D A CaugantR K Selander
Jan 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·W A HankinsJ S Samuelson
Jan 1, 1982·Reviews of Infectious Diseases·J M Griffiss
Jun 1, 1993·The Journal of Infectious Diseases·H K GuttormsenC O Solberg
Jun 1, 1993·The Journal of Infectious Diseases·J F WangM Achtman

❮ Previous
Next ❯

Citations

Jan 1, 1997·The Journal of Urology·S M GoldmanE J McGuire
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory R MoeBecca A Flitter
Nov 30, 1999·Clinical and Diagnostic Laboratory Immunology·M C MaidenI M Feavers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.